摘要
目的:分析老年高血压患者予以缬沙坦联合苯磺酸氨氯地平治疗的效果。方法:选取2021年1月—2023年6月南通市第六人民医院老年高血压患者80例为研究对象,采用随机数表法分为对照组和观察组,各40例。对照组采用苯磺酸氨氯地平治疗,观察组在对照组基础上联合缬沙坦治疗。比较两组血压水平、同型半胱氨酸、肾功能、凝血功能、不良反应。结果:治疗前,两组舒张压、收缩压、同型半胱氨酸水平比较,差异无统计学意义(P>0.05);治疗后,两组舒张压、收缩压、同型半胱氨酸水平均降低,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血尿素氮、肌酐水平比较,差异无统计学意义(P>0.05);治疗后,两组血尿素氮、肌酐水平均降低,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组活化部分凝血活酶时间、纤维蛋白原、D-二聚体水平比较,差异无统计学意义(P>0.05);治疗后,两组活化部分凝血活酶时间升高,观察组高于对照组,纤维蛋白原、D-二聚体水平降低,观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:缬沙坦结合苯磺酸氨氯地平治疗能降低血压水平,降低同型半胱氨酸水平,改善肾功能及凝血功能,安全性好。
Objective:To analyze the effect of valsartan combined with amlodipine besylate in elderly patients with hypertension.Methods:Eighty elderly patients with hypertension in Nantong Sixth People's Hospital from January 2021 to June 2023 were se⁃lected as the research subjects,and were divided into a control group and an observation group using the random number table method,with 40 cases in each group.The control group was treated with amlodipine besylate,and the observation group was treated with valsartan on the basis of the control group.The blood pressure levels,homocysteine,renal function,coagulation func⁃tion,and adverse reactions were compared between the two groups.Results:Before treatment,there was no statistically significant difference in diastolic blood pressure,systolic blood pressure,and homocysteine levels between the two groups(P>0.05);after treat⁃ment,the diastolic blood pressure,systolic blood pressure,and homocysteine levels in both groups were reduced,and the observa⁃tion group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the blood urea nitrogen and creatinine levels between the two groups(P>0.05);after treat⁃ment,the blood urea nitrogen and creatinine levels of both groups were reduced,and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the activated partial thromboplastin time,fibrinogen,and D-dimer levels between the two groups(P>0.05);after treatment,the activated partial thromboplastin time of the two groups increased,and the observation group was higher than that of the control group,the levels of fibrinogen and D-dimer decreased,and the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of ad⁃verse re
作者
朱婧
Zhu Jing(Department of Geriatric Medicine,Nantong Sixth People's Hospital,Nantong 226000,Jiangsu Province,China)
出处
《中外医药研究》
2024年第5期87-89,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
老年高血压
缬沙坦
苯磺酸氨氯地平
肾功能
同型半胱氨酸
凝血功能
Hypertension in the elderly
Valsartan
Amlodipine besylate
Renal function
Homocysteine
Coagulation function
