摘要
目的观察晕宁合剂治疗急性单侧前庭病(AUVP)的临床疗效。方法选取120例患者随机分为对照组与治疗组。对照组采用甲泼尼龙琥珀酸钠,治疗组在对照组的基础上加用晕宁合剂,治疗开始前和治疗后第3、7、14天分别进行视频头脉冲试验(vHIT),记录增益值及不对称值,同时比较炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)]、眩晕障碍量表(DHI)评分、视觉模拟量表(VAS)评分以及中医症状积分的变化。结果治疗后治疗组的炎性因子(TNF-α、IL-6、hs-CRP、NLR、PLR)、DHI评分、VAS评分、中医症状积分低于对照组(P<0.05);治疗组vHIT的增益值高于对照组(P<0.05),不对称值低于对照组(P<0.05);治疗组的临床总有效率为93.33%,优于对照组的78.33%(P<0.05)。结论晕宁合剂联合甲泼尼龙琥珀酸钠对AUVP的治疗效果优于单纯使用甲泼尼龙琥珀酸钠。
Objective:To observe the clinical efficacy of Yunning Mixture in the treatment of acute unilateral vestibulopathy(AUVP)based on v-HIT.Methods:A total of 120 patients were randomly divided into a control group and a treatment group.The control group was treated with methylprednisolone sodium succinate,and the treatment group was treated with Yunning Mixture on the basis of the control group;v HIT was performed before the start of treatment and on the 3rd,7th and 14th days after the start of treatment;the gains and asymmetric values were recorded,and the changes of inflammatory factors(TNF-α,interleukin-6,hypersensitive C-reactive protein,NLR,PLR),Dizziness Handicap Inventory(DHI)score,visual analogue scale(VAS)score and TCM symptom score in the same period were compared.Results:After treatment,the inflammatory factors(TNF-α,interleukin-6,hypersensitive C-reactive protein,NLR,PLR),DHI score,VAS score,and TCM symptom score in the treatment group were lower than those in the control group(P<0.05);the gain value of vHIT in the treatment group was higher than that in the control group(P<0.05),and the asymmetric value was lower than that in the control group(P<0.05);the total clinical effective rate in the treatment group was 93.33%,which was better than 78.33%in the control group(P<0.05).Conclusion:The effect of Yunning Mixture combined with methylprednisolone sodium succinate in the treatment of AUVP is better than that of methylprednisolone hydrochloride sodium succinate.
作者
张若怡
姜文
王丹丹
倪红辉
Zhang Ruoyi;Jiang Wen;Wang Dandan;Ni Honghui(Nantong Hospital of Traditional Chinese Medicine,Jiangsu,Nantong 226000,China)
出处
《中国中医急症》
2024年第4期658-661,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
南通市科技局课题(MSZ18265,MS22022048)。
关键词
急性单侧前庭病
前庭神经炎
晕宁合剂
视频头脉冲试验
中医药疗法
Acute unilateral vestibulopathy
Vestibular neuritis
Yunning Mixture
Video head pulse test
Tradi-tional Chinese medicine therapy
