摘要
目的:探讨复方甘草酸苷片联合恩替卡韦治疗乙型肝炎肝硬化的临床效果。方法:选取2022年8月—2023年8月南宁市宾阳县人民医院收治的乙型肝炎肝硬化患者76例为研究对象,随机分为观察组和对照组,各38例。对照组采用恩替卡韦治疗,观察组在对照组基础上给予复方甘草酸苷片治疗。比较两组临床疗效、凝血功能、肝功能、肝纤维化指标。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.022)。治疗后,两组纤维蛋白原水平高于治疗前,且观察组高于对照组,两组凝血酶原时间、国际化标准值水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组总胆红素、丙氨酸氨基转移酶和天门冬氨酸氨基转移酶水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.001)。治疗后,两组透明质酸、层黏蛋白和Ⅳ型胶原水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:复方甘草酸苷片联合恩替卡韦治疗乙型肝炎肝硬化临床效果理想,可改善患者凝血功能与肝功能,逆转肝纤维化。
Objective:To investigate the clinical effect of compound glycyrrhizin tablets combined with entecavir in the treatment of hepatitis B cirrhosis.Methods:A total of 76 patients with hepatitis B cirrhosis were selected as the study objects at Binyang County People's Hospital of Nanning City from August 2022 to August 2023,and were randomly divided into observation group and control group,with 38 cases in each group.The control group was treated with Entecavir,and the observation group was treated with compound glycyrrhizin tablets based on the control group.The clinical efficacy,coagulation function,liver function and liver fibrosis indexes were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.022).After treatment,the fibrinogen level of the two groups was higher than before treatment,and the observation group was higher than the control group,the prothrombin time and international standard value of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of total bilirubin,alanine aminotransferase and aspartate aminotransferase in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.001).After treatment,the levels of hyaluronic acid,laminin and type IV collagen in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion:Compound glycyrrhizin tablet combined with Entecavir has ideal clinical effect in the treatment of hepatitis B cirrhosis,which can improve coagulation function,liver function and reverse liver fibrosis.
作者
覃桂清
Qin Guiqing(Binyang County People's Hospital,Nanning 530405,Guangxi Zhuang Autonomous Region,China)
出处
《中外医药研究》
2024年第6期21-23,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
乙型肝炎
肝硬化
复方甘草酸苷片
恩替卡韦
凝血功能
肝功能
肝纤维化
Hepatitis B
Liver cirrhosis
Compound glycyrrhizin tablet
Entecavir
Coagulation function
Liver function
Liver fibrosis
