摘要
由炎症和肿瘤中的糖酵解增强引起的乳酸积累是疾病发生或发展的重要环节。2019年,赵英明教授团队发现了组蛋白乳酸化——一种全新的蛋白质翻译后修饰,提出了“乳酸时钟”这个概念,即乳酸通过表观遗传机制促进巨噬细胞极化状态的转变,从而缓解炎症带来的组织损伤。自此以后,各种细胞中的越来越多的乳酸化位点不断被发掘,包括单核巨噬细胞、肿瘤细胞、小胶质细胞等,而乳酸化在其中发挥的功能也因细胞的种类及状态不同而有所不同。本文介绍了乳酸化这一新型蛋白质翻译后修饰,并总结了其在免疫调控中的作用及机制,旨在为乳酸化更多生物学功能的发现提供基础,也为疾病靶向治疗提供新视角。
The accumulation of lactate,caused by increased glycolysis in inflammation and tumors,is an important part of the onset or progression of disease.In 2019,Professor Yingming Zhao’s team discovered histone lactylation,a novel post-translational modification of proteins,and proposed the concept of the“lactate clock”,where lactate promotes a shift in the polarization state of macrophages through an epigenetic mechanism to alleviate tissue damage caused by inflammation.Since then,lactylation sites have been discovered in a variety of cells,including monocyte-macrophages,tumor cells,microglia,and others.The functions that lactylation performs vary depending on the type and state of the cell.This review introduces lactylation,a novel post-translational modification of proteins,and summarizes its role and mechanism in immune regulation,with the aim of providing a basis for the discovery of further biological functions of lactylation,as well as new perspectives for disease-targeted therapy.
作者
陈思憬
杨子轩
曹竞文
钟翠萍
CHEN Sijing;YANG Zixuan;CAO Jingwen;ZHONG Cuiping(The Second Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Otolaryngology Head and Neck Surgery,the 940th Hospital of Joint Logistics Support Force of the Chinese People’s Liberation Army,Lanzhou 730000,China)
出处
《生命的化学》
CAS
2024年第3期423-430,共8页
Chemistry of Life
基金
甘肃省青年科技基金计划项目(20JR10RA013)。
关键词
乳酸化
免疫
翻译后修饰
炎症
lactylation
immunity
post-translational modification
inflammation
