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NRG1联合MRI总负荷量对脑小血管病认知功能障碍的预测价值 被引量:1

NRG1 combined with Total MRI Burden on Cerebral Small Vessel Cognitive Dysfunction of the Predicted Value
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摘要 目的 分析探究神经调节蛋白1(NRG1)与磁共振成像(MRI)总负荷评分对脑小血管病认知功能障碍的预测价值。方法 选择2021年10月至2022年10月河南科技大学第二附属医院收治的符合标准的124例脑小血管病(CSVD)高危人群及血管性认知功能障碍(VCI)住院患者进行回顾性分析研究。根据蒙特利尔认知评估量表(MoCA)以及血管性认知障碍程度将其分为非痴呆型血管性认知障碍(VCIND)组、血管性痴呆(VD)组、认知功能正常(CN)组。通过酶联免疫吸附实验检测血清中NRG1表达水平;根据MRI检查结果,计算CSVD影像学标志物总体负荷评分。将血清NRG1表达水平、MRI总负荷评分与CSVD认知功能障碍进行相关性分析。用NRG1与MRI负荷量构建对血管性认知功能障碍的预测模型。结果 VD组患者血清NRG1表达水平均明显高于CN组,差异具有统计学意义(P <0.05)。Pearson分析显示三组患者血清中NRG1表达水平、MRI总负荷评分与MoCA评分均呈负相关,具有统计学意义(P <0.05)。Logistic回归分析显示血清NRG1、MRI总负荷量均是CSVD认知功能下降的独立危险因素。受试者工作特征(ROC)曲线分析显示血清NRG1和MRI总负荷值单独和联合检测对CSVD所致认知功能障碍均具有较高的诊断价值,具有统计学意义(P <0.05);其中联合检测的诊断价值最高(AUC=0.923)。结论 血清NRG1检测联合MRI总负荷量对CSVD认知功能障碍具有良好的预测价值。 Objective To analyze and explore the predictive value of Neuregulin 1(NRG1) and the total load score of Magnetic Resonance Imaging(MRI) for cognitive impairment in cerebral small vessel disease.Methods A retrospective analysis study was conducted on 124 high-risk individuals with cerebral small vessel disease(CSVD) and inpatients with vascular cognitive impairment(VCI) who were admitted to the Second Affiliated Hospital of Henan University of Science and Technology from October 2021 to October 2022.According to the Montreal Cognitive Assessment(MoCA) and the degree of vascular cognitive impairment,they were divided into non-dementia vascular cognitive impairment(VCIND) group,vascular dementia(VD) group,and cognitively normal(CN) group.The expression level of NRG1 in serum was detected by enzyme-linked immunosorbent assay;according to the results of MRI examination,the total load score of CSVD imaging markers was calculated.The expression level of serum NRG1,MRI total load score,and CSVD cognitive impairment were analyzed for correlation.A predictive model for vascular cognitive impairment was constructed with NRG1 and MRI load.Results The average serum NRG1expression level in the VD group was significantly higher than that in the CN group,and the difference was statistically significant(P < 0.05).Pearson analysis showed that the expression level of NRG1 in serum,MRI total load score,and MoCA score in the three groups were negatively correlated,which was statistically significant(P < 0.05).Logistic regression analysis showed that serum NRG1 and MRI total load were independent risk factors for the decline of cognitive function in CSVD.Receiver operating characteristic(ROC) curve analysis showed that the single and combined detection of serum NRG1 and MRI total load value had a high diagnostic value for cognitive impairment caused by CSVD,which was statistically significant(P < 0.05);among them,the diagnostic value of combined detection was the highest(AUC=0.923).Conclusion The combined detection of serum NRG1and MR
作者 张慧慧 张云 张瑜 李克家 范心华 安惠娟 ZHANG Huihui;ZHANG Yun;ZHANG Yu;LI Kejia;FAN Xinhua;AN Huijuan(Department of Emergency Stroke,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)
出处 《临床研究》 2024年第5期1-5,共5页 Clinical Research
基金 2023年度河南省医学科技攻关计划联合共建项目(LHGI20230841)。
关键词 神经调节蛋白1 MRI总负荷量 脑小血管病 认知功能障碍 neuregulin 1 total MRI load cerebral small vessel disease cognitive dysfunction
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