摘要
目的:探索多普勒超声血流参数及血清脑钠肽(BNP)、胰岛素生长因子-1(IGF-1)水平与子痫前期(PE)病情及预后的相关性。方法:回顾性分析2019年2月至2021年5月万宁市人民医院收集的162例孕妇临床资料,将其中80例正常妊娠孕妇纳入健康对照组,82例PE孕妇纳入观察组。均进行血清BNP、IGF-1以及超声检测,根据受试者工作特征(ROC)曲线下面积(AUC),分析血流阻力指数(RI)、血管指数(VI)、肾脏血流指数(FI)、IGF-1及BNP诊断效能。采用相关性分析血流参数、血清指标与预后相关性。结果:观察组BNP为(90.61±41.71)pg/ml高于健康对照组,差异有统计学意义(t=12.334,P<0.05),VI为(17.35±4.86)%、FI为(34.29±5.55)、IGF-1为(110.35±33.36)g/L,均低于健康对照组,差异有统计学意义(t=7.483、10.163、15.147,P<0.05)。观察组中轻度PE为48例,重度PE为34例,重度PE的BNP为(121.46±37.75)pg/ml高于轻度PE,VI为(13.94±0.24)%、FI为(30.47±3.23)、IGF-1为(89.86±24.17)g/L均低于轻度PE,经Spearman法分析,病情严重程度和预后与VI、FI、IGF-1呈负相关性,与BNP呈正相关性。ROC曲线分析显示,RI、VI、FI、IGF-1、BNP及5项联合诊断重度PE的AUC值分别为0.500、0.888、0.873、0.772、0.862、0.983。观察组中预后良好67例,预后不良15例,预后不良BNP为(87.56±16.35)pg/ml,高于预后良好,差异有统计学意义(t=15.804,P<0.05),VI为(18.60±4.70)%、FI为(33.40±3.56)、IGF-1为(112.35±35.22)g/L,均低于预后良好,差异有统计学意义(t=2.574、5.362、8.750,P<0.05)。结论:血清BNP、IGF-1水平以及多普勒超声血流参数与子痫前期病情、预后存在一定相关性,可为后续治疗、预后提供客观依据。
Objective:To explore the correlation between Doppler ultrasound blood flow parameters,serum brain natriuretic peptide(BNP)and insulin growth factor-1(IGF-1)with the disease condition and prognosis of preeclampsia(PE).Methods:A retrospective analysis was conducted on 162 pregnant women at Wanning People's Hospital from February 2019 to May 2021.Among them,80 normal pregnant women were included in the healthy control group,and 82 PE pregnant women were included in the observation group.All of them underwent serum BNP,IGF-1 and ultrasound examination.Based on the receiver operating characteristic(ROC)curve,the diagnostic efficacies of blood flow resistance index(RI),vascular index(VI),renal blood flow index(FI),IGF-1 and BNP were analyzed.The correlation between blood flow parameters,serum indicators and prognosis were analyzed through correlation analysis.Results:The BNP of the observation group was(90.61±41.71)pg/mL,which were higher than those of the healthy control group(t=12.334,P<0.05).The VI,FI and IGF-1 of observation group were respectively(17.35±4.86)%,(34.29±5.55)and(110.35±33.36)g/L,which were respectively lower than those of the healthy control group,and the differences were statistically significant(t=7.483,10.163,15.147,P<0.05).In the observation group,there were 48 cases of mild PE and 34 cases of severe PE.The BNP of patients with severe PE was(121.46±37.75)pg/mL,which was higher than that of patients with mild PE.The VI,FI and IGF-1 of patients with severe PE were respectively(13.94±0.24)%,(30.47±3.23)and(89.86±24.17)g/L,which were respectively lower than those of patients with mild PE.According to Spearman's analysis,both the severity and prognosis of the disease were negatively correlated with VI,FI,and IGF-1,and were positively correlated with BNP.ROC curve analysis showed that the area under curve(AUC)values of RI,VI,FI,IGF-1,BNP and the combined diagnoses of the 5 indicators were respectively 0.500,0.888,0.873,0.772,0.862 and 0.983 in diagnosing severe PE.In the observation group,there
作者
李辉丽
李秋枫
冯业平
石莉
李香玉
Li Huili;Li Qiufeng;Feng Yeping;Shi Li;Li Xiangyu(Ultrasound Department,Wanning People's Hospital,Wanning 571500,China;Ultrasound Department,Hainan General Hospital,Haikou 570311,China)
出处
《中国医学装备》
2024年第4期84-89,共6页
China Medical Equipment
基金
海南省卫生健康委员会科研项目(21A200248)。
