摘要
[目的]探讨基因预测的血清睾酮水平与全身多部位动脉粥样硬化是否存在因果关系。[方法]基于两项分别来自国外的关于睾酮与动脉粥样硬化的欧洲人群全基因组关联研究汇总数据库,采用两样本孟德尔随机化分析方法,将与睾酮相关的遗传变异数据作为工具变量,利用逆方差加权法、MR-Egger回归和加权中位数估计等方法评估睾酮与动脉粥样硬化之间的因果效应。[结果]逆方差加权法分析结果显示,基因预测的血清睾酮水平与外周动脉粥样硬化的风险呈负相关(OR=0.93,95%CI:0.86~1.00,P=0.01),睾酮升高可能减少患外周动脉粥样硬化的风险,而与脑动脉粥样硬化、冠状动脉粥样硬化及其他部位动脉粥样硬化(除脑动脉、冠状动脉和外周动脉)之间均未发现潜在因果关联的证据(P>0.05)。[结论]孟德尔随机化分析结果显示睾酮与外周动脉粥样硬化发生的风险有一定的因果关系,睾酮治疗在动脉粥样硬化防治中的前景值得开拓及进一步研究。
Aim To study whether genetically predicted serum testosterone level is causally associated with systemic multisite atherosclerosis.Methods Based on two pooled databases of genome-wide association studies on testosterone and atherosclerosis in European populations from two separate foreign countries,the causal effect between testosterone and atherosclerosis was assessed using two-sample Mendelian randomization analysis with data on testosterone-associated genetic variants as instrumental variables(IV),and by using the inverse-variance weighted(IVW)method,MR-Egger regression,and weighted median estimation.Results IVW results showed that genetically predicted circulating testosterone levels were negatively associated with the risk of peripheral atherosclerosis(OR=0.93,95%CI:0.86~1.00,P=0.01),and that elevated testosterone level may reduce the risk of developing peripheral atherosclerosis,while no evidence of a potential causal association was found with cerebral atherosclerosis,coronary atherosclerosis and other atherosclerosis type(P>0.05).Conclusion The final analysis showed a causal relationship between genetically predicted testosterone level and the risk of developing peripheral atherosclerosis,and the role of testosterone therapy in the prevention and treatment of atherosclerosis deserves attention and further study.
作者
胡嘉仪
刘泓岑
龚胜兰
谢天
张天奉
HU Jiayi;LIU Hongcen;GONG Shenglan;XIE Tian;ZHANG Tianfeng(Department of Cardiovascular Medicine,Shenzhen Hospital of Guangzhou University of Chinese Medicine(Futian),Shenzhen,Guangdong 518034,China;The Sixth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong 518034,China)
出处
《中国动脉硬化杂志》
CAS
2024年第4期339-346,共8页
Chinese Journal of Arteriosclerosis
基金
广东省中医药局科研项目(20184018)
深圳市福田区卫生公益性科研项目(FTWS2020007)
中国博士后科学基金面上资助(2023M740855)。
