摘要
目前杀菌剂分子设计多依赖于已知的靶标蛋白,但重复针对相同靶标使用杀菌剂,无疑会增大有害生物对药剂的交互抗性风险。因此,基于新的作用靶标开发新型作用机制的杀菌剂,可以有效解决病原菌对现有杀菌剂的抗性难题。漆酶是二羟基萘黑色素生物合成途径中的关键酶,目前许多研究表明其缺失可使真菌生长发育及致病侵染受到影响,可作为农用杀菌剂潜在靶标进行系统研究。本文介绍了漆酶的结构与功能,并着重介绍了近几年有漆酶抑制活性的化合物作为潜在杀菌剂的研究进展,可为更多新型漆酶抑制剂作为杀菌剂的研究提供指导。
Consequently,identifying new green fungicides has become critical.Currently,the molecular design of fungicides depends on known targets,but the repeated use of fungicides targeting a single pathway undoubtedly increases the risk of cross-resistance in harmful organisms.Therefore,the development of fungicides with novel mechanisms of action based on new targets can effectively solve the problem of pathogenic bacteria resistance to existing fungicides.Laccase is a key enzyme in the biosynthesis pathway of dihydroxynaphthalene melanin.Its absence can affect fungal growth and development and pathogenic infestation,and may be investigated as a potential target for pesticide fungicides.This paper introduces the structure and functionality of laccase,spotlighting recent advances in the study of compounds with laccase inhibitory activity as promising agents.With the hope of providing guidance for the discovery of more novel laccase inhibitors as fungicides.
作者
路星星
孙腾达
徐欢
杨新玲
刘西莉
张晓鸣
凌云
LU Xingxing;SUN Tengda;XU Huan;YANG Xinling;LIU Xili;ZHANG Xiaoming;LING Yun(Innovation Center of Pesticide Research,Department of Applied Chemistry,College of Science,China Agricultural University,Beijing 100193,China;College of Plant Protection,China Agricultural University,Beijing 100193,China)
出处
《农药学学报》
CAS
CSCD
北大核心
2024年第2期290-300,共11页
Chinese Journal of Pesticide Science
基金
国家自然科学基金项目(22077137,21472236).
关键词
漆酶
杀菌剂靶标
漆酶抑制剂
抑菌活性
氨基硫脲衍生物
laccase
fungicide target
laccase inhibitors
antifungal activity
thiosemicarbazide derivatives
