摘要
心肌纤维化是多种心血管疾病发生发展的重要病理过程,与患者预后密切相关。活化的成纤维细胞(CFs)是其中主要的效应细胞,其表面特异性高表达成纤维细胞激活蛋白(FAP)。核素标记的FAP抑制剂(FAPIs)能与FAP特异性结合,在体可视化活化的CFs,在多种心血管疾病的早期诊断、预后预测及干预指导中表现出初步的临床应用价值。该文就核素标记的FAPIs在心血管疾病显像中的研究进展进行综述。
Myocardial fibrosis is an important pathological process in the development of cardiovascular diseases,which is closely related to the prognosis of patients.Activated cardiac fibroblasts(CFs)are the main effector cells,whose surface specifically overexpress fibroblast activation protein(FAP).Radionuclide-labeled FAP inhibitors(FAPIs)can specifically bind to FAP to visualize activated CFs in vivo,showing preliminary clinical application in the early diagnosis,prognosis prediction and interventional guidance of various cardiovascular diseases.This article reviews the progress of researches on the application of radionuclide-labeled FAPIs in cardiovascular diseases imaging.
作者
韩佳莉
李莉
武萍
宋建波
李思进
Han Jiali;Li Li;Wu Ping;Song Jianbo;Li Sijin(Department of Nuclear Medicine,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Cancer Center,Third Hospital of Shanxi Medical University,Taiyuan 030032,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2024年第4期244-248,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
国家自然科学基金(81901785)。
