摘要
非感染性葡萄膜炎是一种严重威胁视力,治疗棘手的自身免疫性眼病。目前主流观点认为非感染性葡萄膜炎的发病机制是主要由CD4+T细胞介导的免疫失衡。但近年来许多证据表明B细胞也发挥关键作用,通过产生抗体、抗原提呈、分泌细胞因子、形成异位淋巴结构等多种方式参与到实验性自身免疫性葡萄膜炎模型及人类葡萄膜炎中。针对B细胞的治疗已广泛应用于多种自身免疫性疾病。利妥昔单抗,一种B细胞抑制剂,在对传统皮质类固醇和免疫抑制剂治疗无效的难治性非感染性葡萄膜炎中发挥不错疗效。本文总结了B细胞在非感染性葡萄膜炎中的作用及细胞疗法,旨在为更深入的机制研究提供理论基础,并为开发精准有效的防治策略开辟新视角。
Non-infectious uveitis,an autoimmune disease that can cause severe visual impairment,can be difficult to treat.According to the prevailing hypothesis,the immune-mediated imbalance that contributes to non-infectious uveitis is primarily driven by CD4+T cells.However,recent research has shown that B cells also play a significant role in this process,participating in various ways such as antibody production,antigen presentation,and cytokine secretion in both human uveitis and experimental autoimmune uveitis models.Therapies targeting B cells have been used extensively in various autoimmune diseases.Rituximab,a B-cell inhibitor,is effective in treating noninfectious uveitis that is unresponsive to conventional corticosteroid and immunosuppressive therapy.This paper provides an overview of the involvement of B cells in non-infectious uveitis and their potential use in cellular therapies,aiming to further investigate the mechanisms and develop more effective strategies for prevention and treatment.
作者
杨园缘
王芷若
陈功
陈慧慧
Yang Yuanyuan;Wang Zhiruo;Chen Gong;Chen Huihui(Department of Ophthalmology,the Second Xiangya Hospital,Central South University,Changsha 410011,Hunan Province,China)
出处
《国际眼科杂志》
CAS
2024年第5期718-722,共5页
International Eye Science
基金
国家自然科学基金面上项目(No.81970804)。
