摘要
目的测定甘肃不同产地当归中22种无机元素含量,并进行主成分分析。方法采用微波消解-电感耦合等离子体质谱(ICP-MS)法同时测定甘肃不同地区所产当归中22种无机元素的含量,同时对《中华人民共和国药典》中规定的5种有害重金属元素(铜、铅、砷、汞、镉)进行危害指数评估,并对不同产地当归中各无机元素进行主成分分析。结果33批当归中铜、铅、砷、汞、镉等5种金属元素的检出率均为100%,但均未超过限度,危害指数评估不存在非致癌健康风险;其余17种元素中可表征当归产地的特征元素为铁、锰、钛、镁、锌、锶、铝,且含量较高的为铁、镁、铝、锰,其中铝最高含量可达3654.9 mg/kg;岷县当归中铁元素含量整体较其他产区高。结论该测定方法具有简便、快速、准确等优点;当归中铝元素的含量较高,具有很大的安全隐患,今后应予以重视。
Objective To determin the content of 22 inorganic elements in Angelica sinensis from different producing areas in Gansu Province,and principal component analysis was performed.Methods Microwave digestion and inductively coupled plasma mass spectrometry(ICP-MS)were used to determine the contents of 22 inorganic elements in Angelica sinensis from different regions of Gansu Province,and the hazard index of 5 harmful heavy me-tals(copper,lead,arsenic,mercury and cadmium)stipulated in Pharmacopoeia of the People's Republic of China were evaluated.The principal components of inorganic elements in Angelica sinensis from different producing areas were analyzed.Results The detection rates of 5 metal elements including copper,lead,arsenic,mercury and cadmium in 33 batches of Angelica sinensis were 100%,but they did not exceed the limit,and the hazard index assessment has no non-carcinogenic health risk.Among the other 17 elements,the characteristic elements that can represent Angelica sinensis origin are iron,manganese,titanium,magnesium,zinc,strontium and aluminum,and the higher content is iron,magnesium,aluminum and manganese,among which the highest content of aluminum can reach 3654.9 mg/kg.The iron content of Angelica sinensis in Min County was higher than that in other producing areas.Conclusion The method is simple,rapid and accurate.The content of aluminum elements is high,which has great safety risks and should be paid attention to in the future.
作者
李欣
高天鹏
王娟弟
郭晓霞
张明童
马潇
LI Xin;AO Tianpeng;WANG Juandi;CUO Xiaoxia;ZHANG Mingtong;MA Xiao(Department of Chinese and Tibetan Medicine,Gansu Institute of Drug Testing,Lanzhou,Gansu,730070,China;State Drug Administration Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces,Lanzhou,Gansu,730070,China)
出处
《甘肃中医药大学学报》
2024年第1期61-70,共10页
Journal of Gansu University of Chinese Medicine
基金
中药材及饮片质量控制重点实验室项目(2022GSMPA-KL12,2022GSMPA-KL10,2021GSMPA-KL04)
甘肃省药品科研项目(2022GSMPA0020,2022GSMPA0017,2022GSMPA0075)。
关键词
当归
无机元素
微波消解-电感耦合等离子体质谱法
含量测定
主成分分析
Angelica sinensis
inorganic elements
microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS)
content determination
principal component analysis
