摘要
目的分析乙型肝炎(hepatitis B virus,HBV)相关肝衰竭患者的甲胎蛋白(alpha-fetoprotein,AFP)、白介素-6(interleukin-6,IL-6)在预后预测中的应用价值。方法选取2020年7月至2022年6月于宜宾市第二人民医院感染科进行治疗的135例HBV相关肝衰竭患者(观察组)为研究对象,另选取同期在该院进行健康体检且各项指标正常者100例为对照组。对比两组研究对象血清AFP、IL-6水平;分析影响HBV相关肝衰竭患者预后的单因素;采用多元logistic回归分析影响HBV相关肝衰竭患者预后的危险因素。结果对照组血清AFP、IL-6水平均低于对照组,差异有统计学意义(P<0.05);两组临床症状为肝性脑病、肝肾综合征、腹水、疾病种类、血清AFP、IL-6水平比较,差异有统计学意义(P<0.05)。经多元logistic回归分析显示:临床症状为肝性脑病、肝肾综合征、腹水以及AFP≥25μg/L、IL-6>10.0 pg/mL是影响HBV相关肝衰竭预后的危险因素。结论血清AFP、IL-6对HBV相关肝衰竭患者预后具有一定的预测作用,值得临床研究。
Objective To analyze the application value of alpha-fetoprotein(AFP)and interleukin-6(IL-6)in prognosis prediction of hepatitis B virus(HBV)associated liver failure.Methods A total of 135 patients with HBV-related liver failure who underwent treatment at the Infection Department of the Second People′s Hospital of Yibin City from July 2020 to June 2022 were selected as the study subjects(observation group).Additionally,100 patients who underwent physical examination in the hospital during the same period with normal indicators were selected as the control group.Serum levels of AFP and IL-6 were compared between the two groups.Factors influencing the prognosis of HBV-related liver failure were analyzed.Multiple logistic regression was used to analyze the risk factors affecting the prognosis of HBV-related liver failure patients.Results The levels of serum AFP and IL-6 in the control group were lower than those in the control group,and the difference was statistically significant(P<0.05).The two groups showed statistically significant differences in clinical symptoms such as hepatic encephalopathy,hepatorenal syndrome,ascites,and disease type(P<0.05).Multiple logistic regression analysis showed that the clinical symptoms of hepatic encephalopathy,hepatorenal syndrome,ascites and AFP≥25μg/L and IL-6>10.0 pg/mL were risk factors affecting the prognosis of HBV-related liver failure.Conclusion Serum AFP and IL-6 can predict the prognosis of patients with HBV-related liver failure,which is worthy of clinical study.
作者
姚玲
陈超
YAO Ling;CHEN Chao(Department of Infection,The Second People′s Hospital of Yibin,Yibin,Sichuan 644000,China)
出处
《公共卫生与预防医学》
2024年第3期141-144,共4页
Journal of Public Health and Preventive Medicine
关键词
乙型肝炎
肝衰竭
甲胎蛋白
白介素-6
预后预测
Hepatitis B virus
Liver failure
Alpha-fetoprotein
Interleukin-6
Prognostic prediction
