摘要
目的探讨腰大池置管引流术联合万古霉素鞘内注射治疗开颅术后颅内感染的临床效果。方法选取2017年1月至2023年1月我院收治的80例开颅术后颅内感染患者,随机分为两组各40例。对照组采用盐酸万古霉素静脉滴注治疗,观察组采用腰大池置管引流术联合万古霉素鞘内注射治疗。比较两组的治疗效果、颅内压与脑脊液相关指标。结果观察组的治疗总有效率为95.00%,显著高于对照组的77.50%(P<0.05)。治疗后,观察组的颅内压以及脑脊液中白细胞计数、蛋白质水平均显著低于对照组,脑脊液中葡萄糖水平显著高于对照组(P<0.05)。结论腰大池置管引流术联合万古霉素鞘内注射治疗开颅术后颅内感染效果显著,可明显降低患者颅内压,改善患者的脑脊液指标。
Objective To explore the clinical effect of lumbar cistern drainage combined with intrathecal injection of vancomycin in the treatment of intracranial infection after craniotomy.Methods Eighty patients with intracranial infection after craniotomy admitted to our hospital from January 2017 to January 2023 were selected and randomly divided into two groups,with 40 cases in each group.The control group was treated with intravenous infusion of vancomycin hydrochloride,while the observation group was treated with lumbar cistern drainage combined with intrathecal injection of vancomycin.The treatment effect,intracranial pressure,and cerebrospinal fluid related indicators were compared between the two groups.Results The total effective rate of the observation group was 95.00%,significantly higher than 77.50%of the control group(P<0.05).After treatment,the intracranial pressure,and the levels of white blood cell count and protein in the cerebrospinal fluid of the observation group were significantly lower than those of the control group,while the glucose level in the cerebrospinal fluid was significantly higher than that of the control group(P<0.05).Conclusions Lumbar cistern drainage combined with intrathecal injection of vancomycin in the treatment of intracranial infection after craniotomy has a significant effect,which can obviously reduce intracranial pressure and improve cerebrospinal fluid indicators of patients.
作者
刘雷震
王贵聪
张圣旭
LIU Leizhen;WANG Gucong;ZHA NG Shengxu(Department of Neurosurgery,Kaifeng Central Hospital,Kaifeng 475000,China)
出处
《临床医学工程》
2024年第4期455-456,共2页
Clinical Medicine & Engineering
关键词
腰大池置管引流术
万古霉素鞘内注射
开颅术后颅内感染
Lumbar cistern drainage
Intrathecal injection of vancomycin
Intracranial infection after craniotomy
