摘要
为探究不同产地栀子中栀子苷及无机元素的分布规律与药材质量间的内在联系,为栀子的质量安全评价及资源开发利用提供基础数据,采用微波消解-电感耦合等离子体质谱、微波消解-电感耦合等离子体发射光谱及高效液相色谱法对7个不同产地栀子的栀子苷及无机元素含量进行测定。结果显示,各产地栀子中栀子苷含量均符合《中国药典》要求,栀子中含有丰富的无机元素,重金属及有害元素未超过《中国药典》限值要求。采用单因子污染指数法和内梅罗综合污染指数法评价了栀子的重金属安全风险性,结果显示重金属含量是安全的。采用Pearson相关性分析了栀子苷与无机元素含量的内在联系,结果表明栀子苷与Fe,Al,Be,V呈正相关,无机元素对栀子苷的积累可能有协同作用。t检验分析结果表明,江西产区栀子与其他产区栀子有显著差异的无机元素为Mg,Be,Sb。
To explore the internal relationship between the distribution of geniposide and inorganic elements in Fructus Gardeniaes from different producing areas and the quality of medicinal materials,and to provide basic data for the quality and safety evaluation and resource development and utilization of Fructus Gardeniae,microwave digestion inductively coupled plasma mass spectrometry,microwave digestion inductively coupled plasma emission spectroscopy,and high performance liquid chromatography were used to determine the content of geniposide and inorganic elements in Fructus Gardeniaes from 7 different regions.The results showed that the content of geniposide in Fructus Gardeniaes met the requirements of the Chinese Pharmacopoeia.Fructus Gardeniae was rich in inorganic elements,heavy metals and the harmful elements did not exceed the limits of the Chinese Pharmacopoeia.The single factor pollution index method and Nemero comprehensive pollution index method were used to evaluate the safety risk of heavy metals in Fructus Gardeniaes,and the results showed that the content of heavy metals was safe.Pearson correlation analysis was used to analyze the internal relationship between geniposide and inorganic element content.The results showed that geniposide was positively correlated with Fe,Al,Be and V,and inorganic elements may have a synergistic effect on the accumulation of geniposide.The t-test analysis showed that the inorganic elements with significant differences between Fructus Gardeniaes from Jiangxi and other producing areas were Mg,Be and Sb.
出处
《上海化工》
CAS
2024年第2期38-44,共7页
Shanghai Chemical Industry
关键词
栀子
无机元素
相关性
安全性
Fructus Gardeniae
Inorganic elements
Correlation
Safety
