摘要
目的:观察大柴胡汤联合非诺贝特治疗高脂血症患者的效果。方法:选取2021年5月至2023年3月该院收治的60例高脂血症患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各30例。对照组使用非诺贝特治疗,研究组在对照组基础上联合大柴胡汤治疗,比较两组临床疗效、治疗前后血脂指标[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和三酰甘油(TG)]水平、炎性指标[胱抑素C(CysC)、同型半胱氨酸(Hcy)、C反应蛋白(CRP)和降钙素原(PCT)]水平、不良反应发生率和血清脂联素(APN)水平。结果:研究组治疗总有效率为93.33%(28/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);治疗后,研究组TC、TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05);治疗后,研究组CysC、Hcy、CRP、PCT水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,两组血清APN水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。结论:大柴胡汤联合非诺贝特治疗高脂血症患者可提高治疗总有效率和血清APN水平,改善血脂指标水平,降低炎性指标水平,效果优于单纯非诺贝特治疗。
Objective:To observe effects of Dachaihu decoction combined with Fenofibrate in treatment of patients with hyperlipidemia.Methods:A prospective study was conducted on 60 patients with hyperlipidemia admitted to the hospital from May 2021 to March 2023.According to the random number table method,they were divided into control group and study group,30 cases in each group.The control group was treated with Fenofibrate,while the study group was treated with Dachaihu decoction on the basis of that of the control group.The clinical efficacy,the blood lipid indexes[total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and triglyceride(TG)]levels,the inflammatory factors[cystatin C(CysC),homocysteine(Hcy),C-reactive protein(CRP)and procalcitonin(PCT)]levels,the incidence of adverse reactions,and the serum adiponectin(APN)levels were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 93.33%(28/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TC,TG and LDL-C in the study group were lower than those in the control group,the level of HDL-C was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CysC,Hcy,CRP and PCT in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After the treatment,the serum APN levels of the two groups were higher than those before the treatment,that in the study group was higher than,that in the control group,and the differences were statistically significant(P<0.05).Conclusions:Dachaihu decoction combined with Fenofibrate in the treatment of the patients with hyperlipidemia can improve the total effective rate of treatment and the se
作者
桑燕舞
郭元明
SANG Yanwu;GUO Yuanming(Longhu Hospital of Henan No.3 Provincial People’s Hospital,Department of Comprehensive Internal Medicine,Zhengzhou 450000 Henan,China;Longhu Hospital of Henan No.3 Provincial People’s Hospital,Neurological Department,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2024年第7期112-114,118,共4页
Medical Journal of Chinese People’s Health
关键词
大柴胡汤
非诺贝特
高脂血症
血脂
炎性指标
脂联素
不良反应
Dachaihu decoction
Fenofibrate
Hyperlipidemia
Blood lipid
Inflammatory factor
Adiponectin
Adverse reaction
