摘要
通过单因素分析和响应面试验来探究火麻仁多肽泡腾片制备的最优工艺及其质量标准评价.以综合评分为指标,考察辅料的配比与添加量,采用响应面法设计出最优方案.通过筛选最优方案为润滑剂添加量为4.58%、崩解剂添加量为43.35%、崩解剂配比为1.2∶1、矫味剂添加量为1.82%.并对火麻仁多肽泡腾片进行质量标准评价及初步稳定性考察,以多肽泡腾片的外观性状、硬度、崩解时限、pH值、脆碎度、微生物限度等作为检测指标.结果表明,均符合《中国药典》相关规定,具有良好的稳定性.通过单因素和响应面试验对火麻仁多肽进行了系统研究,为火麻仁多肽泡腾片制备提供了理论参考和指导.
This paper explored the optimal preparation process and quality standard evaluation of hemp seed peptide effervescent tablets through single factor analysis and response interviews.Using a comprehensive score as an indicator,examine the proportion and amount of excipients added,and use response surface methodology to design the optimal solution.Through screening,the optimal plan was to add 4.58%lubricant,43.35%disintegrant,1.2[DK]∶1 disintegrant ratio,and 1.82%flavor correction agent.And quality standard evaluation and preliminary stability investigation were conducted on the peptide effervescent tablets of hemp seed.The appearance,hardness,disintegration time limit,pH value,fragility,microbial limit of the peptide effervescent tablets were used as detection indicators.The results indicated that they all complied with the relevant provisions of the Chinese Pharmacopoeia and have good stability.This paper conducted a systematic study on hemp seed peptides through single factor and response interviews,providing theoretical reference and guidance for the preparation of hemp seed peptide effervescent tablets.
作者
陶悦
王孜硕
张坤
熊志伟
梁伟
TAO Yue;WANG Zishuo;ZHANG Kun;XIONG Zhiwei;LIANG Wei(College of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Heilongjiang Provincial Key Laboratory of Drug Prevention and Treatment for Senile Diseases,Harbin 150076,China)
出处
《哈尔滨商业大学学报（自然科学版）》
CAS
2024年第2期147-156,共10页
Journal of Harbin University of Commerce：Natural Sciences Edition
关键词
火麻仁
多肽
泡腾片
响应面
综合评分
工艺优化
hemp seed
peptides
effervescent tablet
response surface
comprehensive rating
process optimization
