摘要
目的 分析心肌酶检测在手足口病合并心肌损伤患儿中的诊断价值。方法 选择2020年5月至2023年5月子州县人民医院收治的85例手足口病患儿作为研究对象,根据是否合并心肌损伤分为无心肌损伤组(n=52)和心肌损伤组(n=33),比较两组血清心肌酶水平及检测阳性率,并分析不同检测的诊断价值。结果 心肌损伤组血清乳酸脱氢酶(LDH)、肌酸激酶(CK)、CK同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)水平较无心肌损伤组高,差异有统计学意义(P <0.05);心肌损伤组LDH、CK-MB、CK、cTnI检测阳性率较无心肌损伤组高,差异有统计学意义(P<0.05);LDH单独检测的灵敏度为0.818、特异度为0.865、曲线下面积(AUC)为0.824,CK-MB单独检测的灵敏度为0.697、特异度为0.827、AUC为0.737,CK单独检测的灵敏度为0.727、特异度为0.827、AUC为0.702,cTnI单独检测的灵敏度为0.758、特异度为0.884、AUC为0.842,LDH、CK-MB、CK、cTnI联合检测诊断的灵敏度为0.909、特异度为0.885、AUC为0.910;联合检测的AUC大于各指标单独检测,灵敏度、特异度高于各指标单独检测(P <0.05)。结论 LDH、CK-MB、CK、cTnI联合检测在手足口病合并心肌损伤患儿中的诊断价值较高。
Objective To analyze the diagnostic value of myocardial enzyme detection in children with hand foot mouth disease complicated with myocardial injury.Methods A total of 85 children with hand foot mouth disease admitted to People's Hospital of Zizhou County from May 2020 to May 2023 were selected as the research objects.According to the presence or absence of myocardial injury,they were divided into non-myocardial injury group(n=52)and myocardial injury group(n=33).The levels of serum myocardial enzyme and the positive rate of detection were compared between the two groups,and the diagnostic value of different detection was analyzed.Results The levels of serum lactic acid dehydrogenase(LDH),creatine kinase(CK),CK isoenzymes(CK-MB) and cardiac troponin I(cTnI)in the myocardial injury group were higher than those in the non-myocardial injury group,and the differences were statistically significant(P < 0.05).The positive rates of LDH,CK-MB,CK and cTnI in the myocardial injury group were higher than those in the non-myocardial injury group,and the differences were statistically significant(P < 0.05).The sensitivity,specificity and area under the curve(AUC) of LDH detection alone were 0.818,0.865 and 0.824,those of CK-MB detection alone were 0.697,0.827 and 0.737,those of CK detection alone were 0.727,0.827 and 0.702,respectively.The sensitivity,specificity and AUC of cTnI detection alone were 0.758,0.884 and 0.842,respectively.The sensitivity,specificity and AUC of LDH,CK-MB,CK and cTnI combined detection were 0.909,0.885 and 0.910,respectively.The AUC of combined detection was larger than that of each index alone,and the sensitivity and specificity were higher than those of each index alone(P < 0.05).Conclusion The combined detection of LDH,CK-MB,CK and cTnI has a high diagnostic value in children with hand foot mouth disease complicated with myocardial injury.
作者
刘飞
LIU Fei(Department of Laboratory,People’s Hospital of Zizhou County,Shaanxi Province,Zizhou 718499,China)
出处
《妇儿健康导刊》
2024年第7期122-125,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
心肌酶检测
手足口病
心肌损伤
Detection of myocardial enzyme
Hand foot mouth disease
Myocardial injury
