摘要
目的:探究丹参川芎嗪注射液联合厄贝沙坦分散片治疗原发性高血压的效果,并分析其对颈动脉内膜-中层厚度(IMT)、血管内皮功能的影响。方法:选取2020年9月—2022年9月在山东省泰安荣军医院治疗的原发性高血压患者86例,以随机数字表法将其分为对照组(n=43)及观察组(n=43)。对照组接受厄贝沙坦分散片治疗,观察组接受丹参川芎嗪注射液联合厄贝沙坦分散片治疗。对比两组血压水平[收缩压(SBP)、舒张压(DBP)]、IMT、动脉弹性功能[臂踝脉搏波传导速度(baPWV)、踝臂指数(ABI)、大动脉弹性指数(C1)、小动脉弹性指数(C2)]、血管内皮功能[一氧化氮(NO)、脂质过氧化物(LOP)、内皮素-1(ET-1)]、血清炎症因子[白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)]。结果:治疗前,两组SBP、DBP、IMT比较,差异均无统计学意义(P>0.05);治疗后,两组SBP、DBP、IMT水平均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组baPWV、ABI、C1、C2比较,差异均无统计学意义(P>0.05);治疗后,两组baPWV均降低,C1、C2均升高,观察组baPWV低于对照组,C1、C2均高于对照组,差异均有统计学意义(P<0.05);两组治疗后ABI比较,差异无统计学意义(P>0.05)。治疗前,两组NO、LOP、ET-1比较,差异均无统计学意义(P>0.05);治疗后,两组NO水平均升高,LOP、ET-1水平均降低,观察组NO高于对照组,LOP、ET水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组IL-6、MCP-1比较,差异均无统计学意义(P>0.05);治疗后,两组IL-6、MCP-1水平均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:采用丹参川芎嗪注射液联合厄贝沙坦分散片治疗原发性高血压,血压控制较好,且可改善血管内皮功能及动脉弹性功能,降低IMT和炎症因子水平。
Objective:To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Irbesartan Dispersible Tablets in the treatment of essential hypertension,and to analyze its influence on carotid intima-media thickness(IMT)and vascular endothelial function.Method:A total of 86 patients with essential hypertension treated in Taian Disabled Soldiers'Hospital of Shandong Province from September 2020 to September 2022 were selected and divided into control group(n=43)and observation group(n=43)according to random number table method.The control group was treated with Irbesartan Dispersible Tablets,and the observation group was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Irbesartan Dispersible Tablets.Blood pressure levels[systolic blood pressure(SBP),diastolic blood pressure(DBP)],IMT,arterial elastic function[branchial-ankle pulse wave velocity(baPWV),ankle-brachial index(ABI),great artery elastic index(C1)and small elastic index(C2)],vascular endothelial function[nitric oxide(NO),lipid hydroperoxide(LOP),endothelin-1(ET-1)],serum inflammatory factors[interleukin-6(IL-6),C reactive protein(CRP),monocyte chemotactic protein-1(MCP-1)]of the two groups were compared.Result:Before treatment,there were no significant differences in SBP,DBP and IMT between the two groups(P>0.05).After treatment,the levels of SBP,DBP and IMT in both groups were decreased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in baPWV,ABI,C1 and C2 between the two groups(P>0.05).After treatment,baPWV in both groups were decreased,C1 and C2 in both groups were increased,baPWV in observation group was lower than that in control group,C1 and C2 in observation group were higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in ABI between the two groups after treat
作者
马镇
MA Zhen(Second Disease Area,Taian Disabled Soldiers'Hospital of Shandong Province,Taian 271000,China)
出处
《中国医学创新》
CAS
2024年第9期21-25,共5页
Medical Innovation of China
关键词
丹参川芎嗪注射液
厄贝沙坦分散片
原发性高血压
颈动脉内膜-中层厚度
血管内皮功能
Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection
Irbesartan Dispersible Tablets
Essential hypertension
Carotid intima-media thickness
Vascular endothelial function
