摘要
目的 探讨苏黄止咳胶囊联合丙酸氟替卡松治疗过敏性鼻炎伴咳嗽变异性哮喘的效果。方法 选择2020年3月至2022年6月收治的120例过敏性鼻炎伴咳嗽变异性哮喘患者为研究对象,采用随机数字表法将其分为对照组与观察组,各60例。对照组采取常规治疗+丙酸氟替卡松,观察组在对照组基础上加苏黄止咳胶囊。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组(P<0.05)。治疗前,两组的呼出气一氧化氮(FeNO)、嗜酸性粒细胞(Eos)及哮喘控制测试(ACT)评分无明显差异(P>0.05);治疗后,观察组的FeNO、Eos低于对照组,ACT评分高于对照组(P<0.05)。治疗前,两组的血管内皮细胞黏附分子-1(VCAM-1)、高迁移率族蛋白B1(HMGB1)表达水平无明显差异(P>0.05);治疗后,观察组的VCAM-1、HMGB1表达水平均低于对照组(P<0.05)。结论 苏黄止咳胶囊联合丙酸氟替卡松治疗过敏性鼻炎伴咳嗽变异性哮喘的效果满意,可降低FeNO、Eos,抑制VCAM-1、HMGB1表达,值得推广。
Objective To investigate the effect of Suhuang Zhike capsules combined with fluticasone propionate in the treatment of allergic rhinitis with cough variant asthma.Methods A total of 120 patients with allergic rhinitis and cough variant asthma admitted from March 2020 to June 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with routine treatment+fluticasone propionate,and the observation group was treated with Suhuang Zhike capsules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in fractional exhaled nitric oxide(FeNO),eosinophil granulocyte(Eos)and Asthma Control Test(ACT)score between the two groups(P>0.05);after treatment,the FeNO,Eos in the observation group were lower than those in the control group,and the ACT score was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in the expression levels of vascular cell adhesion molecule-1(VCAM-1)and high mobility group protein B1(HMGB1)between the two groups(P>0.05);after treatment,the expression levels of VCAM-1 and HMGB1 in the observation group were lower than those in the control group(P<0.05).Conclusion Suhuang Zhike capsules combined with fluticasone propionate is effective in the treatment of allergic rhinitis with cough variant asthma,it can reduce the FeNO and Eos,and inhibit the expression of VCAM-1 and HMGB1,which is worthy of promotion.
作者
张娟
刘晓东
牛永亮
ZHANG Juan;LIU Xiaodong;NIU Yongliang(Shenmu Hospital,Yulin 719300,China)
出处
《临床医学研究与实践》
2024年第12期85-88,共4页
Clinical Research and Practice
基金
2022年度卫生健康科研项目(No.2022C006)。
