摘要
目的观察运动针法配合静脉输注英夫利昔单抗及功能训练治疗强直性脊柱炎的临床疗效及其对患者腰椎活动度、疼痛及血清半乳糖凝集素-3(galectin-3)水平的影响。方法将94例强直性脊柱炎患者随机分为治疗组和对照组,每组47例。对照组采用静脉输注英夫利昔单抗和功能训练治疗,治疗组在对照组基础上采用运动针法治疗。观察两组治疗前后腰椎活动度、Bath强直性脊柱炎病情活动指数(Bath ankylosing spondylitis disease activity index,BASDAI)、视觉模拟评分法(VAS)评分、Bath强直性脊柱炎功能指数(Bath ankylosing spondylitis functional index,BASFI)及血清galectin-3、C反应蛋白(C-reactive protein,CRP)和红细胞沉降率(erythrocyte sedimentation rate,ESR)水平的变化情况,比较两组临床疗效和安全性。结果两组治疗后腰椎活动度及血清galectin-3水平均较同组治疗前显著上升,BASDAI评分、VAS评分和BASFI评分及CRP和ESR水平均显著下降,差异均具有统计学意义(P<0.05)。治疗组治疗后腰椎活动度及血清galectin-3水平明显高于对照组,BASDAI评分、VAS评分和BASFI评分及CRP和ESR水平均明显低于对照组,差异均具有统计学意义(P<0.05)。治疗组治疗后总有效率及治疗期间不良反应发生率分别为89.4%和10.6%,对照组分别为68.1%和31.9%,两组差异均具有统计学意义(P<0.05)。结论运动针法配合静脉输注英夫利昔单抗及功能训练治疗强直性脊柱炎疗效确切,能有效缓解疼痛,提高血清galectin-3水平,降低CRP和ESR水平,且安全性较高。
Objective To observe the clinical efficacy of exercise-based acupuncture plus intravenous infusion of Infliximab and functional training in treating ankylosing spondylitis(AS)and its effects on the lumbar range of motion(ROM),pain,and serum galectin-3 level in the patients.Method Ninety-four AS patients were randomized into a treatment group and a control group,with 47 cases in each group.The control group received the intravenous infusion of Infliximab and functional training,based on which the treatment group received additional exercise-based acupuncture.Before and after the treatment,the lumbar ROM,Bath ankylosing spondylitis disease activity index(BASDAI),visual analog scale(VAS)score,Bath ankylosing spondylitis functional index(BASFI),and serum levels of galectin-3,C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR)were observed.The clinical efficacy and safety evaluation were compared between the two groups.Result After the treatment,the lumbar ROM and serum galectin-3 level increased significantly in both groups,and the BASDAI,VAS,and BASFI scores dropped,as well as the CRP and ESR levels,all showing statistical significance(P<0.05).After the treatment,the lumbar ROM and serum galectin-3 level were higher in the treatment group than in the control group,and the BASDAI,VAS,and BASFI scores and CRP and ESR levels were lower in the treatment group,presenting statistical significance(P<0.05).In the treatment group,the total effective rate and adverse reaction rate during the intervention were 89.4% and 10.6%,respectively,versus 68.1% and 31.9% in the control group,and the between-group differences were statistically significant(P<0.05).Conclusion Exercise-based acupuncture plus intravenous infusion of Infliximab and functional training can produce valid efficacy in treating AS.It can effectively relieve pain,increase the serum galectin-3 level,and reduce the CRP and ESR levels,with a high safety rating.
作者
郭纯良
吴佳
张伟
严晓琴
GUO Chunliang;WU Jia;ZHANG Wei;YAN Xiaoqin(Jiangyou People’s Hospital,Jiangyou 621799,China;Sichuan Province Orthopedic Hospital,Chengdu 610041,China)
出处
《上海针灸杂志》
CSCD
2024年第4期400-404,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
四川省中医药管理局资助项目(2021MS357)。
关键词
针刺疗法
运动针法
脊柱炎
强直性
针药并用
功能训练
半乳糖凝集素3
Acupuncture therapy
Exercise-based acupuncture
Spondylitis,Ankylosing
Acupuncture medication combined
Functional training
Galectin-3
