摘要
目的:观察振腹对厌食症模型大鼠的治疗作用及对其外周血中八肽胆囊收缩素(CCK-8)和胃动素(MTL)含量的影响。方法:按照随机数字表法将40只幼龄大鼠进行分组,分为正常组10只和造模组30只。正常组给予普通饲料喂食。造模组采用病因模拟法构建厌食症模型,造模3周后将其随机分为药物组、振腹组和模型组,每组10只。药物组按0.72 g/(kg·bw)剂量给予健胃消食片灌胃(将0.72 g药物用纯水配制成10 mL药液);正常组和模型组每天上午灌服等体积纯水1次;振腹组予以振腹治疗,每日1次,共治疗21次。检测各组大鼠体质量、摄食量、外周血CCK-8、MTL、胃泌素(GAS)及神经降压素(NT)的含量和小肠推进率。结果:与模型组相比,振腹组与药物组的体质量和摄食量、血清MTL及GAS含量和小肠推进率明显提高,血浆CCK-8、NT含量及胃残留率降低,差异具有统计学意义(P<0.05);但振腹组与药物组比较无统计学差异(P>0.05)。结论:振腹可增加厌食症模型大鼠的进食量和体质量,减少胃内容物的残留,提高小肠推进率,对厌食症具有较好的治疗作用。其作用机理可能与抑制血浆CCK-8和NT分泌,促进血清MTL和GAS释放有关。
Objective:To observe the therapeutic effect of vibrating the abdomen on anorexia model rats,as well as its effects on cholecystokinin octapeptide(CCK-8)and motilin(MTL)in the peripheral blood.Methods:Forty young rats were randomly divided into a normal group(n=10)and a modeling group(n=30).Rats in the normal group were fed common feed.The anorexia model was established by the etiological simulation method in the modeling group,and these rats were further randomly divided into a drug group,a vibrating abdomen group,and a model group 3 weeks after the anorexia model was induced,with 10 rats in each group.The drug group was given Jian Wei Xiao Shi Pian by intragastric administration at a dose of 0.72 g/(kg·bw)(0.72 g drug was dissolved in 10 mL purified water).The normal group and the model group were given purified water once a day in the morning.The vibrating abdomen group was treated with vibrating the abdomen once a day for 21 times.The body mass,food intake,serum CCK-8,MTL,gastrin(GAS),neurotensin(NT)levels,and the intestinal propulsion rate of rats in each group were measured.Results:Compared with the model group,the body mass,food intake,serum MTL and GAS levels,and the small intestine propulsion rate increased significantly,and the serum CCK-8 and NT levels,the gastric residual rate decreased significantly in the vibrating abdomen group and the drug group(P<0.05).There were no significant differences between the vibrating abdomen group and the drug group(P>0.05).Conclusion:Vibrating the abdomen increases the food intake and body mass of anorexia model rats,reduces the residue of gastric contents,improves the small intestine propulsion rate,and therefore has a good therapeutic effect on anorexia.The mechanism may be related to inhibiting the secretion of CCK-8 and NT in plasma and promoting the release of MTL and GAS in serum.
作者
周玲
张岩
谷楠
白卫杰
杨丽芸
李进龙
杨燕萍(翻译)
ZHOU Ling;ZHANG Yan;GU Nan;BAI Weijie;YANG Liyun;LI Jinlong;YANG Yanping(Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Hebei Province Special Care Hospital,Shijiazhuang 050051,China;The Third Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050011,China;不详)
基金
河北省中医药管理局项目,No.2017002。
关键词
推拿
按摩
腹部
振法
胃动素
八肽胆囊收缩素
厌食症
大鼠
Tuina
Massage
Abdomen
Vibrating Manipulation
Motilin
Cholecystokinin Octapeptide
Anorexia
Rats
