摘要
环状RNA(circular RNA,circRNA)是一种具有共价闭环结构的非编码RNA(non-coding RNA,ncRNA),因其具有高稳定性、进化保守性和组织表达特异性的特点,越来越受到人们的关注。现有研究表明,circRNA参与恶性肿瘤等多种疾病的发生发展过程。鼻咽癌是一种起源于鼻咽上皮的恶性肿瘤,在中国华南和东南亚地区高发,发病与EB病毒(Epstein-Barr virus,EBV)感染密切相关。目前放疗和化疗是鼻咽癌治疗的主要手段,复发和远处转移是鼻咽癌患者死亡的主要原因。近年研究表明,circRNA作为基因表达调节因子,在鼻咽癌发生发展过程中发挥着重要的作用,影响着鼻咽癌的进展。本文主要综述了鼻咽癌中表达异常的circRNA,包括EB病毒编码的circRNA,在鼻咽癌发生发展中的研究现状,探讨了circRNA作为鼻咽癌患者治疗的潜在靶点以及诊断和预后标志物的可能性。
Circular RNAs(circRNAs)are a kind of non-coding RNA(ncRNA)with covalent closed-loop structure.They have attracted more and more attention because of their high stability,evolutionary conservatism,and tissue expression specificity.It has shown that circRNAs are involved in the development of a variety of diseases including malignant tumors recently.Nasopharyngeal carcinoma(NPC)is a malignant tumor that occurs in the nasopharynx and has a unique ethnic and geographical distribution in South China and Southeast Asia.Epstein-Barr virus(EBV)infection is closely related to the development of NPC.Radiotherapy and chemotherapy are the mainstays of treatment for NPC.But tumor recurrence or distant metastasis is the leading cause of death in patients with NPC.Several studies have shown that circRNAs,as gene expression regulators,play an important role in NPC and affect the progression of NPC.This review mainly summarized the research status of abnormally expressed circRNAs in NPC and EBV-encoded circRNAs.We also discussed the possibility of circRNAs as a therapeutic target,diagnostic and prognostic marker for NPC.
作者
左思程
王丹
莫勇真
刘宇航
蔡姣迪
郭灿
熊芳
陈国群
ZUO Si-Cheng;WANG Dan;MO Yong-Zhen;LIU Yu-Hang;CAI Jiao-Di;GUO Can;XIONG Fang;CHEN Guo-Qun(Pathology Department,The Fourth Hospital of Changsha,Changsha 410006,China;NHC Key Laboratory of Carcinogenesis,Cancer Research Institute,Central South University,Changsha 410078,China;National Clinical Research Center for Geriatric Diseases,Department of Otolaryngology Head and Neck Surgery,Xiangya Hospital,Central South University,Changsha 410078,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2024年第4期809-821,共13页
Progress In Biochemistry and Biophysics
基金
湖南省卫生健康委重点资助课题(202201043273)
长沙市自然科学基金(kq2202023)资助项目。
关键词
鼻咽癌
环状RNA
EB病毒
发病机制
生物标记物
nasopharyngeal carcinoma(NPC)
circular RNAs(circRNAs)
Epstein-Barr virus(EBV)
pathogenesis
biomarker
