摘要
Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene BCR-ABL.In addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1 RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1,TLE3,FOXA1,and MAD1.^(2) However,its specific mechanism in CML is not known.
基金
supported by The National Natural Science Foundation of China(No.81770154,81970194,and 82170176)
the National Key Research and Development Program of China(No.2022YFC2705003)
Guangzhou Medical University Discipline Construction Funds(Basic Medicine)(China)(No.JCXKJS2022A05)
Guangzhou Key Discipline of Medicine(Geriatric Medicine)(China)(No.ZDXK202103).
