摘要
目的 探讨系统性免疫炎症指数(SII)与肾癌患者临床特征及预后的相关性。方法 回顾性分析自2008年9月至2013年12月四川大学华西医院收治的1 030例肾癌患者的临床资料。根据中位SII,将患者分为高SII组(n=515,SII≥381.17)与低SII组(n=515,SII<381.17)。比较两组患者主要临床特征。采用Peason线性相关性分析SII与肿瘤大小的相关性。采用受试者工作特征(ROC)曲线评价SII对肾癌患者淋巴结转移的预测价值。采用Kaplan-Meier检验分析两组患者无病生存期、肿瘤特异性生存率、总生存率。结果 两组患者手术切除范围、肿瘤大小、T分期、淋巴结转移、Fuhrman分级、血红蛋白、白细胞、单核细胞、中性粒细胞、淋巴细胞、血小板、SII比较,差异均有统计学意义(P<0.05)。Peason线性相关性分析显示,SII与肿瘤大小呈正相关(r=0.204,P<0.001)。SII预测肾癌患者淋巴结转移的ROC曲线下面积为0.739(95%可信区间0.658~0.820,P<0.001)。与低SII组比较,高SII组患者无病生存期、肿瘤特异性生存率、总生存率均显著降低,差异有统计学意义(P<0.001)。结论 肾癌患者术前SII水平增高与肿瘤大小、T分期、淋巴结转移、Fuhrman分级等有关,是预后不良的独立预测指标。
Objective To investigate the correlation between systemic immune inflammation index(SII)and clinical features and prognosis of patients with renal carcinoma.Methods The clinical data of 1030 patients with renal carcinoma admitted to West China Hospital of Sichuan University from September 2008 to December 2013 were retrospectively analyzed.Based on median SII,patients were divided into high SII group(n=515,SII≥381.17)and low SII group(n=515,SII<381.17).The main clinical features of the two groups were compared.Linear correlation of Peason was used to analyze the correlation between SII and tumor size.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of SII for lymph node metastasis in patients with renal carcinoma.Disease-free survival,tumor-specific survival,and overall survival were analyzed by Kaplan-Meier test.Results There were statistically significant differences in surgical scope,tumor size,T stage,lymph node metastasis,Fuhrman grade,hemoglobin,white blood cells,monocytes,neutrophils,lymphocytes,platelets and SII between two groups(P<0.05).Linear correlation analysis of Peason showed that SII was positively correlated with tumor size(r=0.204,P<0.001).The area under ROC curve for SII prediction of lymph node metastasis in patients with renal cancer was 0.739(95%confidence interval 0.658 to 0.820,P<0.001).Compared with the low SII group,disease-free survival,tumor-specific survival and overall survival in the high SII group were significantly reduced,with statistical significance(P<0.001).Conclusion The increase of SII level before operation is related to tumor size,T stage,lymph node metastasis and Fuhrman grade,and is an independent predictor of poor prognosis in patients with renal cancer.
作者
陈丹
袁正勇
唐亚雄
邵彦翔
胡旭
李响
CHEN Dan;YUAN Zheng-yong;TANG Ya-xiong;SHAO Yan-xiang;HU Xu;LI Xiang(Department of Urology,West China Hospital of Sichuan University,Chengdu 610041;Department of Urology,Chengdu Seventh People's Hospital,Chengdu 610041;Department of Urology,The People's Hospital of Dujiangyan,Dujiangyan 611800)
出处
《临床军医杂志》
CAS
2024年第3期275-279,共5页
Clinical Journal of Medical Officers
基金
四川省自然科学基金项目(2023NSFSC1864)
成都市卫生健康委员会科研课题(2023059)。
关键词
肾癌
系统性免疫炎症指数
临床特征
预后
Renal cancer
Systemic immune inflammation index
Clinical features
Prognosis
