摘要
The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy clinically.Microsatellite instability(MSI)is found in 10%-15%of colorectal cancer(CRC)patients and exhibits different clinical outcomes than microsatellite stable(MSS)patients.Surprisingly,MSI patients have a better prognosis than patients with stable microsatellites.Msl patients exhibit clinical features that are not responsive to chemotherapy,however,Msl patients showed excellent responses to immunotherapy.'Although the subtype classification of MSI is beneficial to the clinical treatment of CRC patients,the mechanism of MSl remains unclear.
基金
supported by grants from National Nature Science Foundation of China(No.81973356,81902826 and 82273963)
Natural Science Foundation of Tianjin(No.21JCZDJC00060 and 21JCYBJC00180)
the Fundamental Research Funds for the Central Universities of Nankai University(No.ZB22010404,3206054,91923101,63213082,and 92122017).
