摘要
该研究运用证据图系统梳理中成药治疗室性早搏的临床研究,了解该领域的证据分布。通过检索PubMed、Cochrane Library、Web of Science、中国知网(CNKI)、万方(Wanfang)、维普(VIP)数据库中关于中成药治疗室性早搏的文献,检索日期为2016年1月至2022年12月。采用图表结合文字的方式对证据进行分析与展示。最终纳入文献164篇,包括干预性研究147篇、观察性研究4篇、系统评价13篇。结果共获得27种中成药,其中参松养心胶囊和稳心颗粒报告频次较高;临床用药存在超适应证使用现象;近年来国内外该领域发文量呈下降趋势;干预性研究的结局指标有8类,动态心电图、临床有效率、安全性、超声心动图报告频次较高,缺乏对β受体阻滞剂减停率、主要心血管事件和药物经济学指标的报告,评价维度单一;纳入文献整体质量较低,降低了研究结论的可信度。未来需更加规范临床用药,提高临床研究质量,开展临床综合评价,为中成药治疗室性早搏提供更健全的科学依据。
This study employed evidence mapping to systematically sort out the clinical studies about the treatment of premature ventricular contractions with Chinese patent medicines and to reveal the distribution of evidence in this field.The articles about the treatment of premature ventricular contractions with Chinese patent medicines were searched against PubMed,Cochrane Library,Web of Science,CNKI,Wanfang,and VIP with the time interval from January 2016 to December 2022.Evidence was analyzed and presented by charts and graphs combined with text.According to the inclusion and exclusion criteria,164 papers were included,including 147 interventional studies,4 observational studies,and 13 systematic reviews.A total of 27 Chinese patent medicines were involved,in which Shensong Yangxin Capsules and Wenxin Granules had high frequency.There were off-label uses in clinical practice.In recent years,the number of articles published in this field showed a decreasing trend.Eight types of outcome indicators were used in interventional studies.Ambulatory electrocardiography,clinical response rate,safety,and echocardiography had high frequency,while the rate ofβ-blocker decompensation,major cardiovascular events,and pharmaceutical economic indicators were rarely reported.The evalua-tion was one-sided.The low quality of the included articles reduced the reliability of the findings.In the future,the clinical use of medicines should be standardized,and the quality of clinical studies should be improved.Comprehensive clinical evaluation should be carried out to provide a sound scientific basis for the treatment of premature ventricular contractions with Chinese patent medicines.
作者
张文杰
汤佳微
李军
武佶
张印明
解紫从
张乐松
孟超
黄炫淳
ZHANG Wen-jie;TANG Jia-wei;LI Jun;WU Ji;ZHANG Yin-ming;XIE Zi-cong;ZHANG Le-song;MENG Chao;HUANG Xuan-chun(Beijing University of Chinese Medicine,Beijing 100029,China;Beijing University of Posts and Telecommunications,Beijing 100876,China;Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Yankuang New Journey General Hospital,Zoucheng 273500,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第5期1397-1405,共9页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81973836)
国家重点研发计划项目子课题(2022YFC3500102)
首都卫生发展科研专项重点攻关项目(2020-1-4151)。
关键词
中成药
室性早搏
随机对照试验
系统评价
观察性研究
证据图
Chinese patent medicine
premature ventricular contraction
randomized controlled trial
systematic review
observational study
evidence map
