摘要
目的:探究依帕司他联合甲钴胺治疗2型糖尿病周围神经病变的临床效果。方法:选择2020年12月—2022年12月贵州医科大学附属白云医院收治的94例2型糖尿病周围神经病变患者作为研究对象,按随机数表法分为两组,各47例。对照组予以甲钴胺治疗,观察组予以依帕司他联合甲钴胺治疗,均持续治疗4周。比较两组临床疗效、神经传导速度、临床症状体征、氧化应激指标及不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组神经传导速度、临床症状体征、氧化应激指标比较,差异无统计学意义(P>0.05)。治疗后,观察组正中神经、腓总神经的运动神经传导速度(MCV)、感觉神经传导速度(SCV)均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组多伦多临床评分系统(TCSS)评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)均高于对照组,丙二醛(MDA)低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为12.77%,高于对照组的8.51%,但两组间比较,差异无统计学意义(χ^(2)=0.448,P=0.504)。结论:依帕司他联合甲钴胺治疗2型糖尿病周围神经病变效果显著,可增加神经传导速度,减轻氧化应激、临床症状,且安全可靠。
Objective:To explore the clinical effect of Epalrestat combined with Mecobalamin in the treatment of type 2 diabetic peripheral neuropathy.Method:A total of 94 patients with type 2 diabetic peripheral neuropathy admitted to the Guizhou Medical University Affiliated Baiyun Hospital from December 2020 to December 2022 were selected as the study objects,and they were divided into two groups according to random number table method,with 47 patients in each group.The control group was treated with Mecobalamin,and the observation group was treated with Epalrestat combined with Mecobalamin for 4 weeks.The clinical efficacy,nerve conduction velocity,clinical symptoms and signs,oxidative stress index and the incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in nerve conduction velocity,clinical symptoms and signs,and oxidative stress indexes between the two groups(P>0.05).After treatment,the motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)of median nerve and common peroneal nerve in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After treatment,the Toronto clinical scoring system(TCSS)scores of both groups were lower than those before treatment,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,superoxide dismutase(SOD)and reduced glutathione(GSH)in the observation group were higher than those in the control group,and malondialdehyde(MDA)was lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 12.77%,which was higher than 8.51%in the control group,the difference was not statistically significant(χ2
作者
唐琪
TANG Qi(Guizhou Medical University Affiliated Baiyun Hospital,Guiyang 550014,China)
出处
《中外医学研究》
2024年第9期136-139,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
2
型糖尿病周围神经病变
依帕司他
甲钴胺
神经传导速度
临床症状体征
氧化应激反应
Type 2 diabetic peripheral neuropathy
Epalrestat
Mecobalamin
Nerve conduction velocity
Clinical symptoms and signs
Oxidative stress response
