摘要
医用同位素是核医学诊疗的物质基础。利用核医学技术对恶性肿瘤、心脑血管、神经退行性疾病等重大疾病进行诊断与治疗具有不可替代的优势。镥-177(^(177)Lu)具有优异的核物理和化学性质,近年来,欧美发达国家已将其广泛应用于靶向核素治疗研究及临床应用,其标记物对神经内分泌肿瘤、前列腺癌等肿瘤的诊断和治疗展示出良好效果。^(177)Lu已被公认为是目前最具前景和市场活力的靶向放射性诊疗一体化核素之一,预计未来全球对^(177)Lu的需求呈爆发式增长。本研究综述了^(177)Lu的制备原理、国内外分离工艺研究现状、未来市场需求和应用前景。
Medical isotopes are the substantial basis of the diagnostic and therapeutic nuclear medicine.There are irreplaceable advantages for utilizing the nuclear medical technology to diagnose and treat the malignant tumors,cardiovascular and cerebrovascular diseases,neurodegenerative diseases and other major diseases.Lutetium-177(^(177)Lu)has excellent nuclear physical and chemical properties.In recent years,^(177)Lu has been widely used in the research and clinical application of targeted nuclide therapy in the western developed countries,and the radio-labeled compounds have showed the good effects in the diagnosis and treatment of tumors,including neuroendocrine tumors,prostate cancer,metastatic disease in bone and etc.^(177)Lu has been recognized as one of the most promising and dynamic economical theranostic targeted medical radio-isotopesand the global demand for ^(177)Lu can be expected to grow explosively in the future.In this text,the preparation principle of ^(177)Lu and current research status of ^(177)Lu separation technology domestically or internationally,the future market demand and the application prospect were briefly introduced.
作者
李波
胡映江
吴建荣
王磊
陈云明
张劲松
罗宁
LI Bo;HU Yingjiang;WU Jianrong;WANG Lei;CHEN Yunming;ZHANG Jinsong;LUO Ning(Nuclear Power Institute of China,Chengdu 610213,China;National Engineering Research Center of Isotope and Medicine,Chengdu 610213,China;Radioisotope Engineering Technology Research Center of Sichuan,Chengdu 610213,China)
出处
《同位素》
CAS
2024年第2期185-194,共10页
Journal of Isotopes
