摘要
目的探讨血清胰岛素样生长因子-1(IGF-1)联合性激素在将快进展型青春期(RPP)女童中的早期诊断价值。方法将2021年3月至2023年3月期间于我院就诊的43例RPP女童作为观察组,将同期于我院接受健康体检的健康女童41例作为对照组。对两组的年龄、体重、身高、出生史资料、性激素水平以及血清IGF-1水平进行对比,并绘制受试者工作特征曲线(ROC)分析IGF-1、黄体生成素(LH)、促卵泡生成素(FSH)在RPP女童中的诊断价值。结果两组年龄、出生史相关资料、父母矮身材情况、母亲孕期疾病史的等一般资料组间比较差异无统计学意义(P<0.05);观察组患儿体重、身高水平均较对照组高(P<0.05);与对照组相比,观察组血清IGF-1、LH以及FSH水平更高,差异有统计意义(P<0.05);血清IGF-1、LH、FSH与联合诊断RPP的ROC曲线下面积(area under curve,AUC)值分别为0.764、0.673、0.768、0.884,与单一指标诊断比较,联合诊断ROC曲线的AUC值更高(P<0.05),IGF-1246.69μg/L、LH 0.595 U/L、FSH 2.94 U/L为预测RPP的最佳截断值。结论血清IGF-1、LH和FSH在RPP女童中处于较高水平,且IGF-1、LH、FSH水平联合检测对RPP女童的早期预测价值较高,有望成为早期RPP的临床诊断指标。
Objective To investigate the value of serum insulin-like growth factor-1(IGF-1)combined with sex hormones in early diagnosis of rapidlyprogressive puberty(RPP)girls.Methods A total of 43 RPP girls who received medical treatment in our hospital from March 2021 to March 2023 were selected as the observation group,and 41 healthy girls who received physical examination in our hospital during the same period were selected as the control group.Age,weight,height,birth history,sex hormone levels and serum IGF-1 levels were compared between the two groups,and receiver operating characteristic curve(ROC)was drawn to analyze the diagnostic value of IGF-1,luteinizing hormone(LH)and folliclestimulating hormone(FSH)in RPP girls.Results There was no significant difference between the two groups in age,birth history,short stature of parents and maternal disease history during pregnancy(P<0.05).The weight and height of children in observation group were higher than those in control group(P<0.05).Compared with the control group,the serum levels of IGF-1,LH and FSH in the observation group were higher,and the differences were statistically significant(P<0.05).The area under curve(AUC)values of serum IGF-1,LH,FSH and combined diagnosis RPP were 0.764,0.673,0.768 and 0.884,respectively,and the AUC value of combined diagnosis ROC curve was higher than that of single indicator diagnosis(P<0.05).IGF-1246.69μg/L,LH 0.595 U/L,FSH 2.94 U/L were the best cut-off values for predicting RPP.Conclusion Serum IGF-1,LH and FSH levels are high in RPP girls,and the combined detection of IGF-1,LH and FSH levels has a high value in the early prediction of RPP girls,and is expected to become a clinical diagnostic indicator for early RPP.
作者
王莉君
刘晶
李强
WANG Li-jun;LIU Jing;LI Qiang(Clinical Gene Amplification Laboratory,Zhoukou Maternal and Child Health Hospital(Children's Hospital),Zhoukou 466000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第4期118-120,共3页
Journal of Rare and Uncommon Diseases
基金
2020年度河南省医学科技攻关计划联合共建项目(LHGJ20200764)。
