摘要
目的分析去甲肾上腺素应用于重症感染性休克患者中的作用与效果。方法随机选取2021年1月—2023年7月于漳州市第二医院就诊的60例重症感染性休克患者为研究对象,通过抽签法随机分为对照组和观察组,各30例。对照组、观察组分别实施多巴胺治疗、去甲肾上腺素治疗。比较两组的治疗效果。结果观察组治疗结束后的心率低于对照组,平均动脉压、中心静脉压测定值高于对照组,C反应蛋白、白细胞计数、中性粒细胞计数、血清降钙素原以及血尿素氮、血肌酐均低于对照组,差异有统计学意义(P均<0.05)。治疗后6、24、48 h,观察组乳酸清除率均高于对照组,差异有统计学意义(P均<0.05)。观察组总有效率(96.67%)高于对照组的76.67%,差异有统计学意义(χ^(2)=5.192,P<0.05)。两组不良反应发生率(6.67%VS 16.67%)比较,差异无统计学意义(χ^(2)=1.456,P>0.05)。结论在重症感染性休克患者治疗中应用去甲肾上腺素能够稳定其血流动力学,减轻炎症反应以及改善肾功能,有助于乳酸清除率以及疗效提升。
Objective To analyze the effect of norepinephrine in patients with severe septic shock.Methods 60 patients with severe septic shock treated in Zhangzhou Second Hospital from January 2021 to July 2023 were randomly selected as the study objects,and randomly divided into control group and observation group by drawing lots,with 30 cases in each group.Control group and observation group were treated with dopamine and norepinephrine respectively.The therapeutic effect of the two groups was compared.Results After treatment,the heart rate of the observation group was lower than that of the control group,and the measured values of mean arterial pressure and central venous pressure of the observation group were higher than those of the control group,C-reactive protein,white blood cell count,neutrophil count,serum procalcitonin,blood urea nitrogen and blood creatinine were lower than those of control group,and the differences were statistically significant(all P<0.05).At 6 h,24 h and 48 h after treatment,the lactic acid clearance rate of observation group were higher than those of control group,and the differences were statistically significant(all P<0.05).The total effective rate of the observation group(96.67%)was higher than that of the control group(76.67%),and the difference was statistically significant(χ^(2)=5.192,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(6.67%vs 16.67%)(χ^(2)=1.456,P>0.05).Conclusion The application of norepinephrine in the treatment of patients with severe septic shock can stabilize their hemodynamics,reduce inflammatory response and improve renal function,contribute to the clearance of lactic acid and improve the therapeutic effect.
作者
颜凤英
蔡惠娜
田承仁
YAN Fengying;CAI Huina;TIAN Chengren(ICU,Zhangzhou Second Hospital,Zhangzhou,Fujian Province,363000 China;Department of Critical Care Medicine,Zhangzhou Second Hospital,Zhangzhou,Fujian Province,363000 China)
出处
《中外医疗》
2024年第3期115-119,共5页
China & Foreign Medical Treatment
