摘要
目的探讨宫颈锥切术联合贞芪扶正胶囊治疗宫颈上皮内瘤变(CIN)的临床疗效。方法选取2020年1月至2022年1月无锡市第八人民医院收治的80例CIN患者作为研究对象,采用随机信封法分为对照组与观察组,每组40例。对照组接受宫颈锥切术治疗,观察组接受宫颈锥切术联合贞芪扶正胶囊治疗。比较两组临床疗效与复发率、免疫功能[T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))]及生命质量[健康状况调查简表(SF-36)]。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组复发率比较差异无统计学意义。治疗前,两组CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较差异无统计学意义;治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)低于治疗前,且观察组CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05)。治疗前,两组情感职能、生理职能、社会功能、精神健康评分比较差异无统计学意义;治疗后,两组情感职能、生理职能、社会功能、精神健康评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论宫颈锥切术联合贞芪扶正胶囊治疗CIN患者效果显著,可明显改善患者自身免疫功能,降低疾病复发率,提高患者生命质量,值得临床推广应用。
Objective To explore the clinical efficacy of cervical conization combined with Zhenqi Fuzheng capsule in the treatment of cervical intraepithelial neoplasia(CIN).Methods A total of 80 CIN patients admitted to Eighth People's Hospital of Wuxi City,Jiangsu Province,from January 2020 to January 2022 were selected as the study subjects,and they were divided into groups according to the random envelope method,with 40 cases in each group.The control group received cervical conization,and the observation group received cervical conization combined with Zhenqi Fuzheng capsule.The clinical efficacy,recurrence rate,and immune function(T lymphocyte subsets[CD4^(+),CD8^(+),CD4^(+)/CD8^(+)]),quality of life(the MOS item short from health survey[SF-36])were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05);there was no significant difference in recurrence rate between the two groups.Before treatment,there was no significant difference in CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups;after treatment,CD4^(+)and CD4^(+)/CD8^(+)of the two groups were higher than before treatment,and CD8^(+)was lower than before treatment,and CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than control group,and CD8^(+)was lower than control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in emotional function,physiological function,social function and mental health scores between the two groups;after treatment,the scores of emotional function,physiological function,social function and mental health in both groups were higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).Conclusion Cervical conization combined with Zhenqi Fuzheng Capsule in the treatment of CIN patients can achieve good results,which can greatly improve the patient's
作者
王惠清
WANG Huiqing(Department of Obstetrics and Gynecology,Eighth People's Hospital of Wuxi City,Wuxi,Jiangsu,214011,China)
出处
《当代医学》
2024年第2期160-163,共4页
Contemporary Medicine
关键词
贞芪扶正胶囊
宫颈上皮内瘤变
宫颈锥切术
免疫功能
Zhenqi Fuzheng capsule
Cervical intraepithelial neoplasia
Cervical conization
Immune function
