摘要
目的使用眼底相干光层析血管成像术(OCTA)测量单眼低度近视儿童双眼黄斑区视网膜、脉络膜血流密度,并探讨其临床意义。方法采用横断面研究,收集2022年6月至2023年2月大连市第三人民医院眼科门诊就诊的8~14岁单眼低度近视儿童45例(90眼)临床资料。经1%环喷托酯睫状肌麻痹后验光,将等效球镜度(SE)-3.00 D~-0.50 D纳入近视眼组,SE+0.25 D~<+2.00 D纳入非近视眼组。使用IOL Master 500测量眼轴(AL)、平均角膜曲率半径(CR),计算轴率比(AL/CR)。使用海德堡SD-OCT进行黄斑区水平线性扫描并获取中心凹下脉络膜厚度(SFCT)值。使用OCTA模块获取3 mm×3 mm的视网膜脉络膜血流图像,通过Image J图形处理软件获取浅层视网膜血管丛(SCP)血流密度、深层视网膜血管丛(DCP)血流密度、脉络膜毛细血管层(CC)血流密度及中心凹无血管区(FAZ)面积。采用Pearson相关分析各血流指标与年龄、AL、CR、AL/CR、SFCT的相关性。结果近视眼组SE和SFCT均小于未近视眼组,而AL和AL/CR均大于未近视眼组,差异均有统计学意义(均P<0.05)。近视眼组DCP血流密度小于非近视眼组,差异有统计学意义(P<0.01);其他血流指标2组比较无统计学差异(均P>0.05)。Pearson相关分析结果显示,近视眼组SCP、DCP血流密度与SE呈正相关(r分别为0.611、0.731,均P<0.05);与AL呈负相关(r分别为-0.568、-0.712,均P<0.05);与AL/CR呈负相关(r分别为-0.557、-0.564,均P<0.05)。非近视眼组SCP、DCP血流密度与AL/CR呈负相关(r分别为-0.615、-0.656,均P<0.05)。2组CC血流密度、FAZ面积与年龄、SE、AL、CR、AL/CR、SFCT无相关性(均P>0.05)。结论单眼低度近视儿童近视眼与非近视眼比较,DCP血流密度降低;近视眼视网膜血流密度与SE、AL、AL/CR相关,非近视眼视网膜血流密度仅与AL/CR相关。
Objective To assess retinal and choroidal blood flow density in the macular regions of children diagnosed with unilateral low myopia using optical coherence tomography angiography(OCTA).This study aimed to investigate the clinical significance of these mea-surements.Methods A cross-sectional study was conducted on 90 eyes of 45 children with monocular myopia and adolescents aged 8 to 14 years who visited the outpatient department of the Ophthalmology of Dalian Third People’s Hospital between June 2022 and February 2023.Optometry was performed after a 1%cyclopentolate cycloplegic muscle paralysis.Eyes with spherical equivalent(SE)-3.00 D to-0.50 D were included in the myopia group,whereas those with SE-0.25 D to<+2.00 D were placed in the non-myopia group.The Master system was used to measure axial length(AL)and corneal curvature radius(CR),and to calculate AL/CR.Heidelberg spectral-domain optical coherence tomography(SD-OCT)was used to perform horizontal linear scanning of the macular area to obtain subfoveal choroidal thickness(SFCT).The OCTA module was used to obtain 3 mm×3 mm choroidal blood flow images,which were imported into ImageJ graphics processing software to obtain the blood flow densities of the superficial choroidal plexus(SCP),deep choroidal plexus(DCP),choroidal capillary(CC),and foveal avascular zone(FAZ).Pearson’s correlation was used to examine the correlations between each blood flow parameter and age,AL,CR,AL/CR,and SFCT.Results The SE and SFCT of the myopia group were smaller(P<0.05)than those of the non-myopia group,whereas the AL and AL/CR were significantly larger(P<0.05)than those of the non-myopia group.The DCP blood flow density in the myopia group was significantly lower than that in the non-myopia group(P<0.01).There was no statistically sig-nificant difference between the residual blood flow parameters of the myopia and non-myopia groups(P>0.05).The Pearson’s correlation analysis indicated that the SCP and DCP blood flow densities in the myopia group were positively correlated
作者
宁吉良
刘丹霞
薛绍飞
刘小钰
许军
NING Jiliang;LIU Danxia;XUE Shaofei;LIU Xiaoyu;XU Jun(Ophthalmic Refractive Center,Dalian Third People’s Hospital,Dalian Municipal Eye Hospital,Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases,Liaoning Provincial Optometry Technology Engineering Research Center,Dalian 116033,China;Department of Optometry and Pediatric Ophthalmology,Shenyang Aier Excellence Eye Hospital,Shenyang 110001,China)
出处
《中国医科大学学报》
CAS
北大核心
2024年第3期224-229,共6页
Journal of China Medical University
基金
辽宁省科技厅“揭榜挂帅”科技攻关专项(2022JH1/10800071)
大连市第三人民医院科研启动专项基金计划(2021ky006)。
关键词
单眼低度近视
相干光层析血管成像术
视网膜
脉络膜
血流密度
mild monocular myopia
optical coherence tomography angiography
retina
choroid
blood flow density
