摘要
肺癌致病机制与香烟烟雾中的致癌物质诱使肺组织细胞恶变有关,但个体对致癌物质代谢能力的不同使得吸烟人群肺癌患病率存在一定差异,人体遗传多态性对香烟致癌物质的致癌效应起到关键性作用。研究认为,吸烟人群基因与肺癌易感性显著相关,CYP450、GSTs、ERCC1、CHRNA5、EGFR、FHIT等基因突变可增加吸烟人群肺癌发生风险。通过明确相关基因参与肺癌发生发展的作用机制及其在化疗药物耐药性方面的影响,将有助于指导临床合理用药。本研究以吸烟人群相关基因与肺癌发生发展的关系予以综述,旨在为吸烟人群肺癌防治提供新思路。
The pathogenesis of lung cancer is related to the malignant transformation of lung tissue cells induced by carcinogens in cigarette smoke,but the individuals’dissimilar abilities to metabolize these carcinogens make the prevalence of lung cancer different in smoking population,and human genetic polymorphism plays a key role in the carcinogenic effect of cigarette carcinogens.Studies have shown that genes related to smoking population are significantly associated with lung cancer susceptibility.Gene mutations like CYP450,GSTs,ERCC1,CHRNA5,EGFR and FHIT can increase the risk of lung cancer in smoking population.By clarifying the role mechanism of involvement of relevant genes in the occurrence and development of lung cancer and their impacts on chemotherapy drug resistance,it will help guide clinical rational drug use.This study reviews the relationships of genes related to smoking population with the occurrence and development of lung cancer so as to provide new ideas for lung cancer prevention and treatment in smoking population.
作者
段依霜
DUAN Yishuang(Guang’an People’s Hospital,Guang’an,Sichuan 638000,China)
出处
《实用预防医学》
CAS
2024年第3期380-384,F0003,共6页
Practical Preventive Medicine
关键词
吸烟人群
基因多态性
肺癌
smoking population
gene polymorphism
lung cancer
