摘要
目的:分析2019年5月至2020年11月北京市东高地社区35~74岁体检人群结直肠癌筛查结果,为结直肠癌早期筛查模式提供一些参考。方法:采用多靶点粪便FIT-DNA联合检测技术检查,阳性人群全结肠镜检查。结果:1963人完成检测,FIT-DNA阳性率14.0%(275/1963),随年龄增长呈增高趋势(χ2=17.990,P=0.000);70~74岁男性阳性率(27.5%)高于同龄女性(15.3%),其他年龄组无性别差异(P<0.000);高血压、糖尿病、经常吸烟、经常饮酒、低学历人群的FIT-DNA阳性率均增高(P<0.05)。肠镜总参与率9.48%(186/1963),FIT-DNA阳性肠镜参检率61.8%(170/275),检出结直肠癌和癌前病变33.9%(63/186);FIT-DNA和肠镜结果的阳性符合率达92.10%,其中肠癌与高级别病变阳性符合率达100%;75.9%(1489/1963)的人同时进行了FIT-DNA及iFOB检查,前者高于后者(χ2=39.78,P<0.001),前者是后者的2.18倍(OR=2.177,95%CI 1.70~22.784)。结论:FIT-DNA可明显提高肠镜检查的参与率,有利于提高肠癌及癌前病变检出率,可以作为社区人群早期筛查结直肠癌一种有效手段。
Objective:To analyze the colorectal cancer screening results of the 35-74-year-old medical check-up population in Beijing Donggaodi community from May 2019 to November 2020,and to provide some references for the early screening pattern of colorectal cancer.Methods:Multi-target fecal FIT-DNA combined detection technique was used for screening,and the positive population was examined by whole colonoscopy.Results:1963 people completed the test,and the FIT-DNA positive rate was 14.0%(275/1963),which tended to increase with age(χ2=17.990,P=0.000);the positive rate was higher in men aged 70~74 years(27.5%)than in women of the same age(15.3%),and there was no gender difference in other age groups(P<0.000);hypertension,diabetes mellitus,frequent smoking,regular alcohol consumption,and low education groups had higher FIT-DNA positivity rates(P<0.05).The total participation rate of colonoscopy was 9.48%(186/1963),the participation rate of FITDNA-positive colonoscopy was 61.8%(170/275),and colorectal cancer and precancerous lesions were detected in 33.9%(63/186);the positive concordance rate between FIT-DNA and colonoscopy results reached 92.10%,among which the positive concordance rate between bowel cancer and high-grade lesions reached 100%;75.9%(1489/1963)had both FIT-DNA and iFOB,with the former being higher than the latter(χ2=39.78,P<0.001)and the former being 2.18 times higher than the latter(OR=2.177,95%CI 1.702~2.784).Conclusion:FIT-DNA can significantly increase the participation rate of colonoscopy,which is beneficial to improve the detection of bowel cancer and precancerous lesions,and can be used as an effective means for early screening of colorectal cancer in community population.
作者
陆艳红
张晗
赵燕萍
谢秋霞
张超彦
LU Yanhong;ZHANG Han;ZHAO Yanping;XIE Qiuxia;ZHANG Chaoyan(Health Management Center,Beijing Aerospace General Hospital,Beijing 100076,China)
出处
《健康体检与管理》
2024年第1期19-22,93,共5页
Journal of Health Examination and Management
基金
中国癌症基金会诺辉健康专项基金(NH2019001)。
关键词
社区
体检人群
多靶点粪便FIT-DNA
结直肠癌
癌前病变
Community
Physical examination population
Multi-targeted fecal FIT-DNA
Colorectal cancer
Precancerous lesions
