摘要
以环戊酮-2-羧酸甲酯为原料,通过缩醛、还原、羰基脱保护三步反应合成2-羟甲基环戊酮。对第三步反应经行优化,在水相中廉价β环糊精高效促进羰基脱保护反应,操作简单、环境友好、经济高效,产率99%。中间产物和目标产物经NMR表征,并详细研究目标产物及其活泼氢的NMR。不同氘代试剂中,产物活泼氢出现在不同位置,通过重水交换,确定产物活泼氢的位置。
2-Hydroxymethylcyclopentanone was synthesized by ketalization,reduction and deprotection using methyl cyclopentanone-2-carboxylate as the raw material.The reaction condition of the third step was optimized to develop a simple,environmentally friendly,and highly efficient method.Cheapβ-cyclodextrin effectively promoted carbonyl deprotection in the aqueous phase,producing the product with 99%yield.The structures of the intermediate and target product were characterized by NMR,and the NMR spectra of its active hydrogen were investigated in detail.In different deuterium reagents,the active hydrogen of the product appears in different positions,which is determined by the exchange of heavy water.
作者
张桂红
闻硕
白鹏涛
宋恒
徐晨
ZHANG Guihong;WEN Shuo;BAI Pengtao;SONG Heng;XU Chen(School of Environmental and Chemical Engineering,Jiangsu University of Science and Technology,Zhenjiang 212100,Jiangsu,China)
出处
《化学研究》
CAS
2024年第2期123-126,共4页
Chemical Research
基金
江苏省自然科学基金项目(BK20210875)。
关键词
2-羟甲基环戊酮
核磁
活泼氢
2-hydroxymethylcyclopentanone
NMR
active hydrogen
