摘要
目的 探讨巴曲酶(BX)联合金纳多注射液(GIS)对突发性耳聋伴眩晕(SDV)患者的临床疗效。方法 回顾性选取2020年4月至2023年1月延安市人民医院收治的SDV患者为研究对象,依据患者治疗方案不同分为BX组(地塞米松联合BX)和GIS组(地塞米松联合BX和GIS)。比较两组患者治疗后临床疗效、听力恢复时间、耳鸣缓解时间、眩晕缓解时间。观察并比较治疗期间不良反应发生情况。比较两组患者治疗前后血清炎症因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(HsCRP)、白细胞介素-6(IL-6)]水平。结果 研究共纳入90例SDV患者,GIS组和BX组分别为49例和41例。GIS组治疗总有效率显著高于BX组(P <0.05)。GIS组听力恢复时间、耳鸣缓解时间和眩晕缓解时间均显著短于BX组(P <0.05)。治疗前,两组血清TNF-α、Hs-CRP和IL-6差异无统计学意义(P> 0.05);治疗后,两组血清TNF-α、Hs-CRP和IL-6水平均较治疗前显著下降(P <0.05);且GIS组水平均低于BX组(P <0.05)。两组不良反应发生率差异无统计学意义(P> 0.05)。结论 GIS联合BX治疗SDV患者疗效显著,可缩短患者听力恢复、耳鸣缓解及眩晕缓解时间,其可能与GIS和BX降低机体炎症水平有关。
Objective To investigate the clinical efficacy of batroxobin(BX)combined with ginaton injection solution(GIS)in patients with sudden deafness with vertigo(SDV).Methods SDV patients admitted to Yan'an City People's Hospital from April 2020 to January 2023 were retrospectively selected as study subjects,and were divided into the BX group(dexamethasone combined with BX)and the GIS group(dexamethasone combined with BX and GIS)based on the different treatment programs of the patients.The clinical efficacy,hearing recovery time,tinnitus relief time and vertigo relief time of the two groups were compared.The occurrence of adverse reactions during treatment were observed and compared.The levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(Hs-CRP),interleukin-6(IL-6)]before and after treatment in the two groups were compared.Results A total of 90 patients with SDV were included in the study,49 and 41 in the GIS and BX groups,respectively.The total effective rate of treatment in the GIS group was significantly higher than that in the BX group(P<0.05).The time for hearing restoration,when tinnitus was relieved,and the time for vertigo to be relieved in the GIS group was significantly shorter than that in the BX group(P<0.05).The total effective rate of treatment in the GIS group was significantly higher than that in the BX group(P<0.05).Before treatment,the differences in serum TNF-α,Hs-CRP and IL-6 between the two groups were not statistically significant(P>0.05);after treatment,the levels of serum TNF-α,Hs-CRP and IL-6 in the two groups were significantly lower than those before treatment(P<0.05);and the levels in the GIS group were lower than those in the BX group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion The efficacy of GIS combined with BX in the treatment of SDV patients is remarkable,which can shorten the time of hearing recovery,tinnitus relief and vertigo relief of the
作者
闫娟
拓明祥
王宏
田青
杨红丽
安丽
石昊
YAN Juan;TUO Mingxiang;WANG Hong;TIAN Qing;YANG Hongli;AN Li;SHI Hao(Department of Otolaryngology Head and Neck Surgery,Yan'an City People's Hospital,Yan'an 716000,Shaanxi Province,China)
出处
《中国药师》
CAS
2024年第3期470-476,共7页
China Pharmacist
基金
延安市科技计划项目(2021YF-15)。
关键词
突发性耳聋
金纳多注射液
巴曲酶
炎症因子
安全性
Sudden deafness
Ginaton injection solution
Batroxase
Inflammatory factors
Safety
