摘要
老药一般认为是上市时间较早,在临床使用多年,且被医药工作者和公众所了解的药品。老药的安全性尚存在很多未知、未解问题。老药的一些不良反应可能目前还不十分清楚;老药在特殊人群中应用的安全性还需要长期监测;老药许多不良反应发生机制研究需加强,大多数不良反应缺乏特异性诊断的生物标记物及有效的防治措施;老药说明书中不良反应相关内容需要不断完善,许多临床用药的安全性问题还有待制定规范的专家共识和指南。
Old drugs are generally considered as drugs that have been on the market for many years and are well known by medical workers and the public.There are still many unsolved problems about the safety of older drugs.Some adverse reactions of old drugs may not be fully understood at present,the safety of their application in special populations still needs long-term monitoring,the study on mechanism of many adverse reactions of old drugs need to be strengthened,and most adverse reactions lack specific diagnostic biomarkers and effective prevention and treatment measures.The adverse reaction content in the old drug labels needs to be continuously improved,and many safety issues in drug application still require standardized expert consensus and guidance.
作者
蔡晧东
Cai Haodong(Adverse Drug Reactions Journal Agency,Beijing 100053,China)
出处
《药物不良反应杂志》
CSCD
2024年第3期129-132,共4页
Adverse Drug Reactions Journal
关键词
药物相关副作用和不良反应
安全性
患者安全
Drug-related side effects and adverse reactions
Safety
Patient safety
