摘要
目的:研究柔肝化瘀汤在酒精性肝硬化患者中的应用效果。方法:以2020年1月—2022年1月本院收治的80例酒精性肝硬化患者为研究对象,采用随机数字表法将患者分为对照组和观察组,每组40例。对照组给予还原型谷胱甘肽治疗,观察组给予柔肝化瘀汤联合还原型谷胱甘肽治疗。比较两组临床疗效、治疗前后肝功指标[天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、γ-谷氨酰转肽酶(GGT)]、肝纤维化指标[层黏连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)]、血清丙二醛(MDA)、超氧化物歧化酶(SOD)、转化生长因子-β_(1)(TGF-β_(1))、甲壳质酶蛋白-40(YKL-40)水平。结果:观察组临床总有效率(95.00%)高于对照组(77.50%)(P<0.05);观察组AST、TBIL、ALT、GGT、LN、PC-Ⅲ、HA、Ⅳ-C、MDA、TGF-β_(1)、YKL-40水平低于对照组,SOD水平高于对照组(P<0.05)。结论:柔肝化瘀汤应用于酒精性肝硬化患者中的疗效可靠,可缓解肝组织氧化应激损伤,抑制肝纤维化,促进肝功能好转。
Objective:To study the application effect of Rougan Huayu decoction in patients with alcoholic cirrhosis.Methods:A total of 80 patients with alcoholic cirrhosis admitted to our hospital from January 2020 to January 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 40 patients in each group.The control group was treated with reduced glutathione,and the observation group was treated with Rougan Huayu decoction combined with reduced glutathione.The clinical efficacy,liver function indexes[aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),gamma-glutamyl transpeptidase(GGT)],liver fibrosis indexes[laminin(LN),hyaluronic acid(HA),typeⅢprocollagen(PC-Ⅲ),typeⅣcollagen(Ⅳ-C)],serum malondialdehyde(MDA),superoxide dismutase(SOD),transforming growth factor-β_(1)(TGF-β_(1)),chitinase protein-40(YKL-40)levels before and after treatment were compared between the two groups.Results:The total clinical effective rate of the observation group(95.00%)was higher than that of the control group(77.50%)(P<0.05);The levels of AST,TBIL,ALT,GGT,LN,PC-Ⅲ,HA,Ⅳ-C,MDA,TGF-β_(1) and YKL-40in the observation group were lower than those in the control group,and the level of SOD was higher than that in the control group(P<0.05).Conclusion:Rougan Huayu decoction is effective in patients with alcoholic cirrhosis,which can alleviate oxidative stress injury of liver tissue,inhibit liver fibrosis,and promote the improvement of liver function.
作者
梁建议
景霆
李士旭
李林运
LIANG Jianyi;JING Ting;LI Shixu;LI Linyun(Department of Endoscopy,Nanyang Hospital of Traditional Chinese Medicine,Nanyang 473000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第2期341-345,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
