摘要
目的:探究细菌溶解产物辅助阿莫西林克拉维酸钾+氨溴特罗用于小儿迁延性细菌性支气管炎的治疗效果.方法:选取我院2021年1月至2022年12月收治88例迁延性细菌性支气管炎患儿作为研究对象,采用单双号法随机分组为观察组和对照组,每组各44例.对照组患儿给予阿莫西林克拉维酸钾+氨溴特罗的治疗方案,观察组患儿在对照组患儿治疗基础上联合细菌溶解产物治疗.观察并比较两组患儿治疗7 d后治疗效果(治疗期间发热、咳嗽、肺部湿啰音消失时间);治疗前及治疗7 d后免疫检测物水平(血清免疫球蛋白A(ImmunoglobulinA,IgA)、血清免疫球蛋白G(ImmunoglobulinG,IgG)、CD4^(+)T淋巴细胞群、CD8^(+)T淋巴细胞群);治疗前及治疗7 d后炎症因子水平(C-反应蛋白(C-reactive protein,CRP)、前降钙素);随访2 m内细菌性支气管炎复发率.结果:治疗后,两组患儿IgA、IgG、CD4^(+)、CD8^(+)水平较治疗前显著提升(P<0.05);且观察组患儿IgA、IgG、CD4^(+)、CD8^(+)水平明显高于对照组,临床症状消失时间、抗生素使用时间、CRP、前降钙素水平和复发率明显低于对照组(P<0.05).结论:细菌溶解产物辅助阿莫西林克拉维酸钾+氨溴特罗可加快迁延性细菌性支气管炎患儿症状消失,减轻炎症反应,提升其免疫水平以降低复发风险,且安全性高,建议临床推广使用.
Objective:To explore the therapeutic effect of bacterial lysates assisted with amoxicillin and clavulanate potassium+ambrocol in the treatment of children with protracted bacterial bronchitis.Methods:88 children with protracted bacterial bronchitis admitted to the hospital from January 2021 to December 2022 were selected as research subjects,and were divided into observation group and control group by the odd-even number random method,with 44 cases in each group.The children in control group were given treatment regimen of amoxicillin and clavulanate potassium+ambrocol,and the children in observation group were additionally treated with bacterial lysates on the basis of control group.The therapeutic effect after 7 days of treatment(disappearance times of fever,cough and lung wet rales during treatment),levels of immune markers(serum immunoglobulin A(IgA),serum immunoglobulin G(IgG),CD4^(+)T lymphocyte population,CD8^(+)T lymphocyte population)before treatment and after 7 days of treatment and levels of inflammatory factors(C-reactive protein(CRP),procalcitonin)before treatment and after 7 days of treatment and recurrence rate of bacterial bronchitis within 2 months of follow-up were observed and compared between both groups of children.Results:After treatment,the levels of IgA,IgG,CD4^(+)and CD8^(+)in both groups were significantly enhanced compared with those before treatment(P<0.05),and the levels of IgA,IgG,CD4^(+)and CD8^(+)in observation group were significantly higher than those in control group,and the disappearance time of each clinical symptom,antibiotic use time,CRP level,procalcitonin level and recurrence rate were significantly shorter or lower than those in control group(P<0.05).Conclusion:Bacterial lysates assisted with amoxicillin and clavulanate potassium+ambrocol can accelerate the symptom disappearance,relieve the inflammatory response,enhance the immunity level and reduce the risk of recurrence in children with protracted bacterial bronchitis,and it has high safety,so it is recommended for clin
作者
温雅铮
朱小晴
Wen Ya-zheng;Zhu Xiao-qing(Department of Pediatrics,Pingdingshan Maternal and Child Health Hospital,Pingdingshan 467000,Henan,China)
出处
《四川生理科学杂志》
2024年第3期571-573,共3页
Sichuan Journal of Physiological Sciences
