摘要
液相色谱-串联质谱技术具有高特异性、高通量的特点, 因此在临床检验领域有快速的应用和发展, 其在治疗药物监测中的应用可有效提升定量准确性与灵敏度, 为患者制定个性化的最佳给药方案。但该技术目前仍面临一些挑战, 自动化、质量控制、量值溯源等将是今后的发展方向。
Liquid chromatography-tandem mass spectrometry(LC-MS/MS)technology has the characteristics of high specificity and high throughput,making it rapidly applied and developed in the field of clinical testing.Its application in the monitoring of therapeutic drugs can effectively improve the quantitative accuracy and sensitivity,and formulate a personalized and optimal dosing plan for patients.However,this technology still faces some challenges,and automation,quality control,and quantitative traceability will be the future development direction.
作者
李姿颖
谢洁
屈子裕
江游
张谛
禹松林
马晓丽
邱玲
戴新华
方向
俞晓平
Li Ziying;Xie Jie;Qu Ziyu;Jiang You;Zhang Di;Yu Songlin;Ma Xiaoli;Qiu Ling;Dai Xinhua;Fang Xiang;Yu Xiaoping(Institute of Inspection and Quarantine,College of Life Sciences,China Jiliang University,Hangzhou 310018,China;Technology Innovation Center of Mass Spectrometry for State Market Regulation,Center for Advanced Measurement Science,National Institute of Metrology,Beijing 100029,China;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2024年第3期332-340,共9页
Chinese Journal of Laboratory Medicine
基金
国家重点研发计划(2020YFF01014600)
国家自然科学基金(21927812)
中国计量科学研究院基本业务费(AKYZZ2325)。
关键词
色谱法
液相
串联质谱法
治疗药物监测
样本前处理
挑战
Chromatography,liquid
Tandem mass spectrometry
Therapeutic drug monitoring
Sample pretreatment
Challenge
