摘要
目的研究重复经颅磁刺激(rTMS)联合度洛西汀对抑郁障碍患者的疗效与安全性。方法选取2022年5月至2023年5月呼伦贝尔市第三人民医院收治的100例抑郁障碍患者作为研究对象,采用计算机程序随机将其分为研究组(50例)和对照组(50例)。对照组采用盐酸度洛西汀肠溶胶囊进行治疗,在给予相同抗抑郁药物治疗的基础上,研究组添加rTMS治疗,比较两组的临床疗效、汉密尔顿抑郁量表(HAMD-17)评分及不良反应发生情况。结果研究组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗2周后,研究组患者的HAMD-17评分低于对照组患者,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论与单用抗抑郁药物相比,rTMS联合抗抑郁药物的疗效更好、安全性更高。
Objective To research the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS)combined with Duloxetine in the treatment of depression.Methods A total of 100 patients with depression admitted to the Third People's Hospital of Hulunbuir from May 2022 to May 2023 were selected as the research subjects.They were divided into observation group and control group using computer program,with 50 patients in each group.The control group was treated with Duloxetine Hydrochloride Enteric-coated Capsules.On the basis of receiving the same antidepressant medication treatment,the observation group was added with rTMS treatment.The clinical efficacy,Hamilton depression scale(HAMD-17)and incidence of adverse reactions were compared between the two groups.Results The treatment effectiveness rate of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).After two weeks of treatment,the HAMD-17 score of observation group patients was lower than that of the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Compared with antidepressants alone,rTMS combined with antidepressants was more effective and safer.
作者
姜蕊琪
JIANG Ruiqi(Department of Pharmacy,the Third People's Hospital of Hulunbuir,Inner Mongolia Autonomous Region,Hulunbuir022150,China)
出处
《中国当代医药》
CAS
2024年第8期63-66,共4页
China Modern Medicine
关键词
抑郁障碍
重复经颅磁刺激
度洛西汀
疗效
安全性
Major depressive disorder
Repetitive transcranial magnetic stimulation
Duloxetine
Efficacy
Security
