摘要
目的探究超声引导下细针穿刺细胞学(FNAC)联合BRAFV600e基因检测在甲状腺癌预后评估中的临床价值。方法选择2020年8月至2022年12月于长江大学附属荆州医院被确诊为甲状腺癌并接受甲状腺癌根治术的121例可疑淋巴结转移患者为研究对象,所有患者术前均接受超声引导下FNAC检测以及BRAFV600e基因检测,以患者术后病理检测结果为金标准,分别计算超声引导下FNAC检测以及BRAFV600e基因检测对甲状腺癌淋巴结转移的诊断价值。结果以病理结果为金标准,超声引导下FNAC对甲状腺癌淋巴结转移的诊断一致性为71.07%(86/121)、诊断敏感度为73.53%(75/102)、诊断特异度为57.89%(11/19);BRAFV600e基因检测对甲状腺癌淋巴结转移的诊断一致性为83.47%(101/121)、诊断敏感度为87.25%(89/102)、诊断特异度为63.16%(12/19);超声引导下FNAC联合BRAFV600e基因检测对甲状腺癌淋巴结转移的诊断一致性为97.52%(118/121)、诊断敏感度为98.04%(100/102)、诊断特异度为94.74%(18/19)。联合检测的诊断一致性、敏感度和特异度均明显高于任一单独检测方式,组间比较差异均有统计学意义(P<0.05)。结论超声引导下FNAC联合BRAFV600e基因检测对甲状腺癌出现淋巴结转移具有较好的诊断效能,较任一单独检测效能更优,建议将其应用于甲状腺癌患者是否出现淋巴结转移的鉴别中。
Objective To explore the clinical value of ultrasound-guided fine needle aspiration cytology(FNAC)combined with BRAFV600e gene detection in prognostic evaluation of thyroid cancer.Methods A total of 121 patients with suspected lymph node metastasis who were diagnosed with thyroid cancer and underwent radical surgery for thyroid cancer at Jingzhou Hospital Affiliated to Yangtze University from August 2020 to December 2022 were selected as the study subjects.All patients had received ultrasound-guided FNAC detection and BRAFV600e gene detection before surgery,and the postoperative pathological test results of the patients were used as the gold standard to calculate the diagnostic value of ultrasound-guided FNAC detection and BRAFV600e gene detection for lymph node metastasis in thyroid cancer.Results Using pathological results as the gold standard,the diagnostic consistency of FNAC guided by ultrasound for lymph node metastasis of thyroid cancer was 71.07%(86/121),the diagnostic sensitivity was 73.53%(75/102),and the diagnostic specificity was 57.89%(11/19).The diagnostic consistency of BRAFV600e gene detection for lymph node metastasis in thyroid cancer was 83.47%(101/121),the diagnostic sensitivity was 87.25%(89/102),and the diagnostic specificity was 63.16%(12/19).The diagnostic consistency of ultrasound-guided FNAC combined with BRAFV600e gene detection for lymph node metastasis in thyroid cancer was 97.52%(118/121),the diagnostic sensitivity was 98.04%(100/102),and the diagnostic specificity was 94.74%(18/19).The diagnostic consistency,sensitivity,and specificity of combined testing were significantly higher than those of any single detection method,with statistically significant differences between groups(P<0.05).Conclusion Ultrasoundguided FNAC combined with BRAFV600e gene detection has good diagnostic efficacy for lymph node metastasis in thyroid cancer,which is superior to any single detection.It is recommended to apply it in the differential diagnosis of lymph node metastasis in thyroid cancer patients.
作者
程诗露
胡锟
朱敏
黄龙凤
CHENG Shiu;HU Kun;ZHU Min;HUANG Longfeng(Vascular&Thyroid Surgery Department,Jingzhou Hospital Affiliated to Yangtze University,Hubei,Jingzhou 434020,China)
出处
《中国医药科学》
2024年第6期147-150,共4页
China Medicine And Pharmacy
基金
湖北省荆州市医疗卫生科技计划项目(2016087)。
