摘要
目的基于网络药理学探讨加味止哮平喘汤治疗支气管哮喘的作用机制。方法获取药物活性成分及关键靶点,然后运用相应数据库预测支气管哮喘的相关靶点,两者取交集后,运用STRING数据库和Cytoscape 3.9.1软件构建蛋白相互作用网络及药物-靶点网络,进行基因本体(GO)功能富集和京都基因与基因组百科全书(KEGG)通路富集分析。结果筛选出核心药物的活性成分404个,交集靶点202个。GO功能分析得到180条分子功能,KEGG通路富集分析得到179条通路。结论通过网络药理学分析,预测了加味止哮平喘汤治疗支气管哮喘的作用机制,为临床研究提供了参考。
Objective To explore the mechanism of action of modified Zhixiao Pingchuan Decoction in the treatment of bronchial asthma based on network pharmacology.Methods The active ingredients and key targets of the drug were obtained,and then the corresponding databases were used to predict the relevant targets of bronchial asthma.After the intersection,the STRING database and Cytoscape 3.9.1 software were used to construct protein-protein interaction networks and drug-target networks,and gene ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed.Results 404 active ingredients and 202 intersection targets of the core drug were screened.180 molecular functions were obtained through GO functional analysis,and 179 pathways were obtained through KEGG pathway enrichment analysis.Conclusion Through network pharmacology analysis,the mechanism of action of modified Zhixiao Pingchuan Decoction in treating bronchial asthma has been predicted,providing a reference for clinical research.
作者
曹悦
王鹏
刘施
杨宏志
CAO Yue;WANG Peng;LIU Shi;YANG Hongzhi(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Hubei,Wuhan 430061,China;Department of Pulmonary Disease,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei,Wuhan 430061,China;Department of Pharmacy,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei,Wuhan 430061,China;The First Clinical College,Hubei University of Chinese Medicine,Hubei,Wuhan 430061,China)
出处
《中国医药科学》
2024年第5期129-132,共4页
China Medicine And Pharmacy
基金
国家中医药管理局全国名老中医药专家(王鹏)传承工作室建设项目(国中医药人教函〔2022〕75号)
湖北省教育厅科学研究计划指导性项目(B2022112)。
关键词
支气管哮喘
网络药理学
加味止哮平喘汤
作用机制
Bronchial asthma
Network pharmacology
Modified Zhixiao Pingchuan Decoction
Mechanism of action
