摘要
目的探究经颅直流电刺激(tDCS)对抑郁症患者的治疗效果,并观察其对患者认知功能的影响,以期为临床应用tDCS治疗抑郁症提供参考依据。方法选取丽水市第二人民医院2023年3—12月收治的抑郁症患者112例为研究对象,依据是否进行tDCS治疗,将患者分为对照组(55例)和tDCS组(57例)。比较2组患者17项汉密顿抑郁量表(HAMD-17)评分、威斯康星卡片分类测验(WCST)评分及不良反应发生情况。结果治疗后,tDCS组患者总有效率高于对照组[89.47%(51/57)vs.69.09%(38/55),P<0.01]。治疗前,2组患者HAMD-17评分、WCST评分比较差异均无统计学意义(P>0.05)。治疗后,2组患者HAMD-17评分明显降低(P<0.05),治疗4周后,tDCS组患者HAMD-17评分低于对照组[(10.64±2.57)分vs.(15.82±2.96)分]。治疗4周后,tDCS组患者WCST中5项评分均优于对照组(P<0.001),患者认知功能改善显著。治疗过程中2组均出现不良反应,对照组恶心1例,tDCS组皮肤刺痛1例,恶心1例,2组患者不良反应发生情况比较差异无统计学意义(P>0.05)。结论tDCS能有效缓解抑郁症患者临床症状,效果明显,并能改善抑郁症患者的认知功能。
Objective To investigate the therapeutic effect of transcranial direct current stimulation(tDCS)on patients with depression,and to observe its influence on the patients'cognitive function in order to provide a reference for the clinical application of tDCS in the treatment of depression.Methods A total of 112 patients with depression admitted to the Second People's Hospital of Lishui from March to December 2023 were selected as observation objects,and divided into control group(n=55)and tDCS group(n=57)according to whether they were treated with tDCS or not.The 17-item Hamilton depression scale(HAMD-17)score,Wisconsin card sorting test(WCST)score,and adverse reactions were compared between the two groups.Results After treatment,the overall efficacy rate of the tDCS group was higher than that of the control group[89.47%(51/57)vs.69.09%(38/55),P<0.01].Before treatment,there was no significant difference in HAMD-17 score and WCST score between the two groups(P>0.05).After treatment,the HAMD-17 scores of both groups were significantly decreased(P<0.05).After 4 weeks of treatment,the HAMD-17 score of the tDCS group was lower than that of the control group[(10.64±2.57)points vs.(15.82±2.96)points].After 4 weeks of treatment,the 5-item WCST scores of the tDCS group were better than those of the control group(P<0.001),and the patients'cognitive function was significantly improved.During treatment,adverse events occurred in both groups,including 1 case of nausea in the control group,1 case of skin tingling,and 1 case of nausea in the tDCS group.There was no statistically significant difference in side effects between the two groups(P>0.05).Conclusion tDCS can effectively relieve the clinical symptoms of depression patients,the effect is obvious,and can improve the cognitive function of depression patients.
作者
曹江
张岩
袁娜华
朱桂东
CAO Jiang;ZHANG Yan;YUAN Nahua;ZHU Guidong(The Sixth Ward of the Second People's Hospital of Lishui,Lishui,Zhejiang 323000,China)
出处
《中华全科医学》
2024年第4期589-591,596,共4页
Chinese Journal of General Practice
基金
浙江省基础公益研究计划项目(LGF22H090055)。
关键词
经颅直流电刺激
抑郁症
认知功能
治疗效果
Transcranial direct current stimulation
Depression
Cognitive function
Therapeutic effect
