摘要
目的探讨双相情感障碍急性期治疗有效后1年的复发率及影响因素。方法收集2021年10月至2022年3月在驻马店市第二人民医院确诊为双相情感障碍急性期患者122例。出院后进行1年随访,依据患者是否复发进行分组调查,即复发组和未复发组。统计治疗有效后1年的复发率,单因素及多因素Logistic回归分析影响双相情感障碍急性期复发的因素。结果随访截止时间为2023年3月,共随访1年,发现复发患者24例(复发组),复发率为19.67%(24/122),未复发组患者98例,未复发率为80.33%(98/122)。单因素分析显示,发作次数、住院次数、残留症状、应用心境稳定剂、诊断类型、工作情况、停药方式、医疗付费方式、存在自杀未遂均可能为双相情感障碍急性期复发的影响因素,差异均具有统计学意义(P<0.05)。多因素Logistic回归分析显示,应用单一心境稳定剂(OR=5.262)、住院次数>2次(OR=1.451)、医疗支付自费(OR=2.813)、迅速停药(OR=1.023)均为双相情感障碍急性期复发的危险因素,差异具有统计学意义(P<0.05)。结论双相情感障碍急性期治疗有效后1年复发率较低,其复发危险因素与应用单一心境稳定剂、住院次数>2次、医疗支付自费、迅速停药有关。
Objective To investigate the one-year relapse rate and influencing factors after effective acute treatment of bipolar affective disorder.Methods A total of 122 patients diagnosed with acute bipolar affective disorder from October 2021 to March 2022 at Zhumadian Second People’s Hospital were collected.A one-year follow-up was conducted after discharge,and the patients were grouped according to whether they relapsed,i.e.,the relapse group and the non-relapse group.The one-year relapse rate after effective treatment was statistically analyzed,and univariate and multivariate logistic regression analyses were used to analyze the factors influencing the relapse of acute bipolar affective disorder.Results As of March 2023,a total of one year of follow-up was conducted,and 24 patients were found to have relapsed(relapse group),with a relapse rate of 19.67%(24/122).There were 98 patients in the non-relapse group,with a non-relapse rate of 80.33%(98/122).Univariate analysis showed that the number of episodes,number of hospitalizations,residual symptoms,use of mood stabilizers,diagnostic type,work situation,drug withdrawal method,medical payment method,and attempted suicide may all be influencing factors for the relapse of acute bipolar affective disorder,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that the use of a single mood stabilizer(OR=5.262),more than 2 hospitalizations(OR=1.451),self-payment for medical treatment(OR=2.813),and rapid drug withdrawal(OR=1.023)were all risk factors for the relapse of acute bipolar affective disorder,and the differences were statistically significant(P<0.05).Conclusion The one-year relapse rate after effective acute treatment of bipolar affective disorder is relatively low,and its risk factors for relapse are related to the use of a single mood stabilizer,more than 2 hospitalizations,self-payment for medical treatment,and rapid drug withdrawal.
作者
王俊
陈亚光
WANG Jun;CHEN Yaguang(Second Department of Psychiatry,Zhumadian Second People’s Hospital(Affiliated Brain Hospital of Zhengzhou University),Zhumadian Henan 463000,China)
出处
《临床研究》
2024年第4期26-29,共4页
Clinical Research
关键词
双相情感障碍
急性期
复发
影响因素
bipolar affective disorder
acute phase
relapse
influencing factors
