摘要
目的:观察癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、糖类抗原72-4(CA72-4)水平联合检测在直肠癌诊断中的效能。方法:回顾性分析2021年2月至2023年5月该院收治的78例直肠癌患者的临床资料,作为直肠癌组;回顾性分析同期该院收治的100例直肠良性肿瘤患者(直肠腺瘤55例,直肠异型增生45例)的临床资料,作为非直肠癌组。比较两组CEA、CA19-9、CA125、CA72-4水平,比较不同直肠肿瘤(直肠癌、直肠腺瘤、直肠异型增生)患者CEA、CA19-9、CA125、CA72-4水平,分析CEA、CA19-9、CA125、CA72-4水平单项及联合检测在直肠癌诊断中的效能(灵敏度、特异度、准确度)。结果:直肠癌组血清CEA、CA19-9、CA125、CA72-4水平均高于非直肠癌组,差异有统计学意义(P<0.05)。不同直肠肿瘤患者CEA、CA19-9、CA125、CA72-4水平比较,差异均有统计学意义(P<0.05)。CEA、CA19-9、CA125、CA72-4水平联合检测诊断直肠癌的准确度、灵敏度、特异度均高于四者单项检测诊断,差异有统计学意义(P<0.05)。结论:CEA、CA19-9、CA125、CA72-4水平联合检测诊断直肠癌的效能高于四者单项检测诊断效能。
Objective:To observe efficiency of combined detection of carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125) and carbohydrate antigen 72-4(CA72-4) levels in diagnosis of rectal cancer.Methods:The clinical data of 78patients with rectal cancer admitted to this hospital from February 2021 to May 2023 were retrospectively analyzed and they were as rectal cancer group.The clinical data of 100 patients with benign rectal tumors(55 cases of rectal adenoma and 45 cases of rectal dysplasia) admitted to this hospital during the same period were retrospectively analyzed and they were used as non-rectal cancer group.The levels of CEA,CA19-9,CA125and CA72-4 were compared between the two groups.The levels of CEA,CA19-9,CA125 and CA72-4 in the patients with different rectal tumors(rectal cancer,rectal adenoma and rectal dysplasia) were compared.The efficiencies(sensitivity,specificity,accuracy) of single and combined detection of CEA,CA19-9,CA125 and CA72-4 levels in the diagnosis of rectal cancer were analyzed.Results:The levels of serum CEA,CA19-9,CA125 and CA72-4 in the rectal cancer group were higher than those in the non-rectal cancer group,and the differences were statistically significant(P<0.05).There were significant differences in the levels of CEA,CA19-9,CA125 and CA72-4 in the patients with different rectal tumors(P<0.05).The accuracy,sensitivity and specificity of combined detection of CEA,CA19-9,CA125 and CA72-4 levels in the diagnosis of rectal cancer were higher than those of single detection of the four,and the differences were statistically significant(P<0.05).Conclusions:The efficiency of combined detection of CEA,CA19-9,CA125 and CA72-4 levels in the diagnosis of rectal cancer is higher than those of the four single detections.
作者
徐萌萌
孙其静
XU Mengmeng;SUN Qijing(Department of Clinical Laboratory of the Affiliated Hospital of Binzhou Medical College,Binzhou 256600 Shandong,China)
出处
《中国民康医学》
2024年第6期123-125,共3页
Medical Journal of Chinese People’s Health
关键词
直肠癌
诊断
效能
癌胚抗原
癌抗原19-9
癌抗原125
糖类抗原72-4
Rectal cancer
Diagnosis
Efficiency
Carcinoembryonic antigen
Cancer antigen 19-9
Cancer antigen 125
Carbohydrate antigen 72-4
