摘要
目的:观察促性腺激素释放激素激动剂(GnRH-a)联合醋酸泼尼松龙治疗子宫内膜异位症合并习惯性流产患者的效果。方法:选取2020年1月至2023年1月该院收治的105例子宫内膜异位症合并习惯性流产患者进行前瞻性研究,按照随机数字表法将其分为研究组(n=53)和对照组(n=52)。对照组采用醋酸泼尼松龙治疗,研究组在对照组基础上联合GnRH-a治疗,比较两组临床疗效,治疗前后卵巢功能指标[卵泡刺激素(FSH)、黄体生成素(LH)]水平、子宫内膜相关参数[阻力指数(RI)、搏动指数(PI)]水平、单核细胞趋化蛋白-1(MCP-1)水平、血管内皮生长因子(VEGF)水平,以及不良反应发生率。结果:研究组治疗总有效率为90.57%(48/53),高于对照组的73.08%(38/52),差异有统计学意义(P<0.05);治疗后,两组FSH、LH、RI、PI水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组VEGF、MCP-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:GnRH-a联合醋酸泼尼松龙治疗子宫内膜异位症合并习惯性流产患者,可提高临床疗效,改善卵巢功能、子宫内膜RI和PI,降低VEGF、MCP-1水平,效果优于单纯醋酸泼尼松龙治疗。
Objective:To observe effects of gona-dotropin-releasing hormone agonist(GnRH-a) combined with Prednisolone acetate in treatment of patients with endometriosis complicated with habitual abortion.Methods:A prospective study was conducted on 105 patients with endometriosis complicated with habitual abortion admitted to the hospital from January 2020 to January 2023.According to the random number table method,they were divided into study group(n=53) and control group(n=52).The control group was treated with Prednisolone acetate,while the study group was treated with GnRH-a on the basis of that of the control group.The clinical efficacy,the ovarian function indexes [follicle stimulating hormone(FSH),luteinizing hormone(LH)] level,the endometrial related parameters [resistance index(RI),pulsatility index(PI)] levels,the monocyte chemoattractant protein-1(MCP-1) level,the vascular endothelial growth factor(VEGF) level before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 90.57%(48/53),which was higher than 73.08%(38/52) in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FSH,LH,RI and PI in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of VEGF and MCP-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:Gn RH-a combined with Prednisolone acetate in the treatment of the patients with endometriosis complicated with habitual abortion can improve the clinical efficacy,improve the ovarian function and the levels of endometrial RI and PI,and r
作者
陶艳林
TAO Yanlin(Department of Obstetrics and Gynecology of Jia County People’s Hospital,Pingdingshan 467100 Henan,China)
出处
《中国民康医学》
2024年第6期71-73,共3页
Medical Journal of Chinese People’s Health
