摘要
目的:观察异甘草酸镁联合还原型谷胱甘肽治疗慢性病毒性肝炎患者的效果。方法:选取2021年2月至2023年1月该院收治的120例慢性病毒性肝炎患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各60例。两组均予以常规治疗,在此基础上,对照组采用还原型谷胱甘肽治疗,研究组在对照组基础上联合异甘草酸镁治疗,两组均治疗12周。比较两组临床疗效,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)]水平、肝纤维化指标[Ⅳ型胶原蛋白(Ⅳ-C)、层粘连蛋白(LN)、透明质酸(HA)]水平、炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)]水平,以及不良反应发生率。结果:研究组治疗总有效率为90.00%(54/60),高于对照组的75.00%(45/60),差异有统计学意义(P<0.05);治疗后,研究组TBIL、ALT、AST水平均低于对照组,ALB水平高于对照组,差异有统计学意义(P<0.05);治疗后,研究组Ⅳ-C、LN、HA、CRP、PCT、WBC水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异甘草酸镁联合还原型谷胱甘肽治疗慢性病毒性肝炎患者可提高治疗总有效率,改善肝功能指标水平,降低肝纤维化指标水平和炎性指标水平,效果优于单纯还原型谷胱甘肽治疗。
Objective:To observe effects of Magnesium isoglycyrrhizinate combined with reduced glutathione in treatment of patients with chronic viral hepatitis.Methods:A prospective study was conducted on 120 patients with chronic viral hepatitis admitted to the hospital from February 2021 to January 2023.According to the random number table method,they were divided into study group and control group,60 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with reduced glutathione,while the study group was treated with Magnesium isoglycyrrhizinate on the basis of that of the control group.Both groups were treated for 12 weeks.The clinical efficacy,the liver function indexes [alanine aminotransferase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),albumin(ALB)] levels,the liver fibrosis indexes [type IV collagen(IV-C),laminin(LN),hyaluronic acid(HA)] levels,the inflammatory indexes [C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)] levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 90.00%(54/60),which was higher than 75.00%(45/60)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TBIL,ALT and AST in the study group were lower than those in the control group,the level of ALB was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IV-C,LN,HA,CRP,PCT and WBC in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Magnesium isoglycyrrhizinate combined with reduced glutathione in the treatment of the patients with chronic viral hepatitis can improve the total effective rate of treatment,improve
作者
赵青
ZHAO Qing(Department of Pharmacy of Shangqiu Municipal Hospital,Shangqiu 476000 Henan,China)
出处
《中国民康医学》
2024年第6期41-44,共4页
Medical Journal of Chinese People’s Health
关键词
异甘草酸镁
还原型谷胱甘肽
慢性病毒性肝炎
肝纤维化
肝功能
不良反应
Magnesium isoglycyrrhizinate
Reduced glutathione
Chronic viral hepatitis
Liverfibrosis
Liver function
Adverse reaction
