摘要
目的:观察藤杖通络颗粒对血瘀型脑小血管病患者红细胞相关指标、血压变异度及中医证候的影响。方法:将60例血瘀型脑小血管病患者分为对照组及治疗组各30例。对照组给予常规西药,治疗组在对照组治疗基础上给予藤杖通络颗粒,两组均口服3个月。比较两组患者治疗前后红细胞相关指标(红细胞数量、红细胞压积、红细胞分布宽度)、24小时动态血压(24小时收缩压变异度、24小时舒张压变异度、平均收缩压、平均舒张压)、中医证候评分、中医证候疗效。结果:(1)对照组中医证候有效率为13.3%(4/30),治疗组有效率为80.0%(24/30),两组比较,差异有统计学意义(P<0.05)。(2)治疗后红细胞压积(42.19±5.23)%、红细胞分布宽度[11.60(11.28,11.90)%]均低于同期对照组(P<0.05)。(3)治疗组24小时收缩压变异度(13.45±2.80)%低于同期对照组(P<0.05)。(4)治疗后,治疗组中医证候积分明显降低(P<0.05),且低于同期对照组(P<0.05)。(5)通过多元Logistic分析,服用藤杖通络颗粒是血瘀型脑小血管病患者中医证候有效的独立治疗因素。结论:藤杖通络颗粒治疗血瘀型脑小血管病疗效显著,可改善患者红细胞相关指标,降低血压波动。
Objective:To evaluate the effects of Tengzhang Tongluo Granule on red blood cell related indicators,blood pressure variability and TCM syndrome in patients with cerebral small vessel disease of blood stasis syndrome.Methods:Sixty patients with cerebral small vessel disease of blood stasis syndrome were divided into a control group and a treatment group,with 30 cases in each group.The control group was given conventional western medicine,while the treatment group was given Tengzhang Tongluo Granule in addition to the control group′s treatment.Both groups were orally administered for 3 months.Compare the red blood cell related indicators(red blood cell count,red blood cell hematocrit,red blood cell distribution width),24-hour dynamic blood pressure(24-hour systolic blood pressure variability,24-hour diastolic blood pressure variability,mean systolic blood pressure,mean diastolic blood pressure),TCM syndrome score and TCM syndrome efficacy between two groups of patients before and after treatment.Results:(1)The effective rate of TCM syndrome in the control group was 13.3%(4/30),while the effective rate in the treatment group was 80.0%(24/30).The difference between the two groups was statistically significant(P<0.05).(2)After treatment,the red blood cell hematocrit(42.19±5.23)%and red blood cell distribution width[11.60(11.28-11.90)%]were significantly lower than those of the control group during the same period(P<0.05).(3)The 24-hour systolic blood pressure variability(13.45±2.80)%in the treatment group was significantly lower than that in the control group during the same period(P<0.05).(4)After treatment,the TCM syndrome score in the treatment group significantly decreased(P<0.05),which was significantly lower than that in the control group during the same period(P<0.05).(5)Through multiple logistic analysis,taking Tengzhang Tongluo Granule is an independent treatment factor for TCM syndrome in patients with cerebral small vessel disease of blood stasis syndrome.Conclusion:Tengzhang Tongluo Granule has a signi
作者
卞跃峰
单莉莉
乔天慈
郭岑
陈春香
刘明媛
韩燕
BIAN Yuefeng;SHAN Lili;QIAO Tianci;GUO Cen;CHEN Chunxiang;LIU Mingyuan;HAN Yan(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai China 200437;Yueyang Clinical Medical College of Shanghai University of Traditional Chinese Medicine,Shanghai China 201203)
出处
《中医学报》
CAS
2024年第4期854-858,共5页
Acta Chinese Medicine
基金
国家重点研发计划中医药现代化专项资助项目(2019YFC1711603)
上海申康医院发展中心重大临床研究项目(SHDC2020CR2046B)。
关键词
脑小血管病
血瘀证
藤杖通络颗粒
红细胞数量
红细胞压积
红细胞分布宽度
血压变异度
中医证候
cerebral small vessel disease
blood stasis syndrome
Tengzhang Tongluo Granule
red blood cell count
red blood cell hematocrit
red blood cell distribution width
blood pressure variability
TCM syndrome
