摘要
目的了解昆明市男男性行为人群(MSM)梅毒新发感染率及其影响因素,为降低本地区该人群梅毒感染率开展综合干预措施提供参考依据。方法2018年6月至2020年12月,采用互联网、同伴推荐和外展动员的综合方式招募MSM建立前瞻性、开放性队列,每6个月随访进行问卷调查和血清学检测。运用Cox回归模型采用单因素和多因素分析方法对MSM梅毒新发感染的影响因素进行分析。结果198名MSM纳入队列,梅毒新发感染率为1.36/100人年。研究对象的性取向[HR=4.526(1.213~112.36)]、交友途径[HR=4.274(1.113~56.285)]、近1年是否被诊断过性病[HR=0.045(0.005~0.433)]差异有统计学意义(P<0.05或P<0.01)。多因素Cox回归分析显示交友途径为非互联网(HR=15.553)、近1年曾被诊断过性病(HR=59.129)是MSM感染梅毒的危险因素。结论虽然昆明市MSM梅毒新发感染率较低,但危险性仍然较高。应采取综合干预模式降低MSM梅毒的新发感染。
Objective To understand the new infection rate of syphilis and its influencing factors among men who have sex with men(MSM)in Kunming,and to provide reference for comprehensive intervention measures to reduce the syphilis infection among MSM.Methods From June 2018 to December 2020,a prospective,open cohort of MSM was re‐cruited using a combination of Internet,peer referral,and outreach.Questionnaires and serological tests were followed up every 6 months.Univariate and multivariate analyses were conducted by Cox regression model to investigate the influencing factors of new syphilis infection among MSM.Results A total of 198 MSM were enrolled in the cohort.The incidence was 1.36 per 100 person‐year for new syphilis infection.There were significant differences in sexual orientation[HR=4.526(1.213-112.36)],ways of making friends[HR=4.274(1.113-56.285)],and whether the subjects had been diag‐nosed with sexually transmitted diseases in the past year[HR=0.045(0.005-0.433)](P<0.05 or P<0.01).Multivariate Cox regression analysis showed that non‐Internet dating(HR=15.553)and sexually transmitted disease diagnosis in the past year(HR=59.129)were risk factors for syphilis infection among MSM.Conclusions Although the new infection rate of syphilis among MSM is low in Kunming,the risk is still high.A comprehensive intervention model should be adopt‐ed to reduce the incidence of syphilis infection.
作者
马婧
蔡永年
李佑芳
王珏
潘颂峰
李志晴
王玉淼
马艳玲
MA Jing;CAI Yongnian;LI Youfang;WANG Jue;PAN Songfeng;LI Zhiqing;WANG Yumiao;MA Yanling(Institute of STDs/AIDS Control and Prevention,Yunnan Provincial Center for Disease Control and Prevention,Kunming 650022,China)
出处
《华南预防医学》
2024年第1期6-9,共4页
South China Journal of Preventive Medicine
基金
国家“十三五”科技重大专项(2018ZX10715-006)。
关键词
男男性行为人群
梅毒
队列研究
新发感染
Men who have sex with men
Syphilis
Cohort study
New infection
